Amphoterin-induced protein 1 (AMIGO1)

About Amphoterin-induced protein 1

Amphoterin-induced protein 1 (AMIGO1) is a protein from Homo sapiens identified by UniProt accession Q86WK6, 493 residues long. MolForge cross-references it against 0 known binders and 52 disease associations.

Target properties

Protein name	Amphoterin-induced protein 1
UniProt accession	Q86WK6
Gene	AMIGO1
Organism	Homo sapiens
Length	493 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (52)

Diseases linked to this target (Open Targets).

self reported educational attainment · score 0.31
mathematical ability · score 0.24
apolipoprotein B measurement · score 0.16
intelligence · score 0.10
attention deficit hyperactivity disorder · score 0.09
sitting height measurement · score 0.08
attention deficit-hyperactivity disorder 8 · score 0.07
schizophrenia 15 · score 0.07
tobacco smoke exposure measurement · score 0.07
Asperger syndrome · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q86WK6-F1	alphafold	PREDICTED	78.06	—

Amino-acid sequence (493 residues)

MHPHRDPRGL WLLLPSLSLL LFEVARAGRA VVSCPAACLC ASNILSCSKQ QLPNVPHSLP SYTALLDLSH NNLSRLRAEW TPTRLTQLHS LLLSHNHLNF ISSEAFSPVP NLRYLDLSSN QLRTLDEFLF SDLQVLEVLL LYNNHIMAVD RCAFDDMAQL QKLYLSQNQI SRFPLELVKE GAKLPKLTLL DLSSNKLKNL PLPDLQKLPA WIKNGLYLHN NPLNCDCELY QLFSHWQYRQ LSSVMDFQED LYCMNSKKLH NVFNLSFLNC GEYKERAWEA HLGDTLIIKC DTKQQGMTKV WVTPSNERVL DEVTNGTVSV SKDGSLLFQQ VQVEDGGVYT CYAMGETFNE TLSVELKVHN FTLHGHHDTL NTAYTTLVGC ILSVVLVLIY LYLTPCRCWC RGVEKPSSHQ GDSLSSSMLS TTPNHDPMAG GDKDDGFDRR VAFLEPAGPG QGQNGKLKPG NTLPVPEATG KGQRRMSDPE SVSSVFSDTP IVV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards