Amphoterin-induced protein 3 (AMIGO3)

About Amphoterin-induced protein 3

Amphoterin-induced protein 3 (AMIGO3) is a protein from Homo sapiens identified by UniProt accession Q86WK7, 504 residues long. MolForge cross-references it against 0 known binders and 28 disease associations.

Target properties

Protein name	Amphoterin-induced protein 3
UniProt accession	Q86WK7
Gene	AMIGO3
Organism	Homo sapiens
Length	504 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (28)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.55
HbA1c measurement · score 0.05
sex hormone-binding globulin measurement · score 0.05
erythrocyte count · score 0.04
FEV/FVC ratio · score 0.04
prostate carcinoma · score 0.03
BMI-adjusted waist circumference · score 0.03
susceptibility to childhood ear infection measurement · score 0.03
self reported educational attainment · score 0.03
major depressive disorder · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q86WK7-F1	alphafold	PREDICTED	73.51	—

Amino-acid sequence (504 residues)

MTWLVLLGTL LCMLRVGLGT PDSEGFPPRA LHNCPYKCIC AADLLSCTGL GLQDVPAELP AATADLDLSH NALQRLRPGW LAPLFQLRAL HLDHNELDAL GRGVFVNASG LRLLDLSSNT LRALGRHDLD GLGALEKLLL FNNRLVHLDE HAFHGLRALS HLYLGCNELA SFSFDHLHGL SATHLLTLDL SSNRLGHISV PELAALPAFL KNGLYLHNNP LPCDCRLYHL LQRWHQRGLS AVRDFAREYV CLAFKVPASR VRFFQHSRVF ENCSSAPALG LERPEEHLYA LVGRSLRLYC NTSVPAMRIA WVSPQQELLR APGSRDGSIA VLADGSLAIG NVQEQHAGLF VCLATGPRLH HNQTHEYNVS VHFPRPEPEA FNTGFTTLLG CAVGLVLVLL YLFAPPCRCC RRACRCRRWP QTPSPLQELS AQSSVLSTTP PDAPSRKASV HKHVVFLEPG RRGLNGRVQL AVAEEFDLYN PGGLQLKAGS ESASSIGSEG PMTT

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards