About Membrane progestin receptor alpha
Membrane progestin receptor alpha (PAQR7) is a protein
from Homo sapiens identified by UniProt accession
Q86WK9, 346 residues long.
MolForge cross-references it against 0 known binders and
70 disease associations.
Target properties
| Protein name | Membrane progestin receptor alpha |
|---|
| UniProt accession | Q86WK9 |
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| Gene | PAQR7 |
|---|
| Organism | Homo sapiens |
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| Length | 346 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (70)
Diseases linked to this target (Open Targets).
- hemoglobin measurement · score 0.25
- BMI-adjusted waist-hip ratio · score 0.19
- hematocrit · score 0.19
- waist-hip ratio · score 0.18
- erythrocyte count · score 0.15
- mean corpuscular hemoglobin concentration · score 0.13
- red blood cell density measurement · score 0.12
- cancer · score 0.08
- lung adenocarcinoma · score 0.07
- triple-negative breast cancer · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q86WK9-F1 | alphafold | PREDICTED | 89.96 | — |
Amino-acid sequence (346 residues)
MAMAQKLSHL LPSLRQVIQE PQLSLQPEPV FTVDRAEVPP LFWKPYIYAG YRPLHQTWRF YFRTLFQQHN EAVNVWTHLL AALVLLLRLA LFVETVDFWG DPHALPLFII VLASFTYLSF SALAHLLQAK SEFWHYSFFF LDYVGVAVYQ FGSALAHFYY AIEPAWHAQV QAVFLPMAAF LAWLSCIGSC YNKYIQKPGL LGRTCQEVPS VLAYALDISP VVHRIFVSSD PTTDDPALLY HKCQVVFFLL AAAFFSTFMP ERWFPGSCHV FGQGHQLFHI FLVLCTLAQL EAVALDYEAR RPIYEPLHTH WPHNFSGLFL LTVGSSILTA FLLSQLVQRK LDQKTK
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