About Nuclear receptor 2C2-associated protein
Nuclear receptor 2C2-associated protein (NR2C2AP) is a protein
from Homo sapiens identified by UniProt accession
Q86WQ0, 139 residues long.
MolForge cross-references it against 0 known binders and
20 disease associations.
Target properties
| Protein name | Nuclear receptor 2C2-associated protein |
|---|
| UniProt accession | Q86WQ0 |
|---|
| Gene | NR2C2AP |
|---|
| Organism | Homo sapiens |
|---|
| Length | 139 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (20)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.48
- Immunodeficiency by defective expression of HLA class 2 · score 0.42
- MHC class II deficiency · score 0.42
- genetic disorder · score 0.17
- non-small cell lung carcinoma · score 0.08
- type 2 diabetes mellitus · score 0.04
- low density lipoprotein cholesterol measurement · score 0.03
- diastolic blood pressure · score 0.03
- neoplasm · score 0.03
- Hypercholesterolemia · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q86WQ0-F1 | alphafold | PREDICTED | 96.49 | — |
Amino-acid sequence (139 residues)
MTHSLVCPET VSRVSSVLNR NTRQFGKKHL FDQDEETCWN SDQGPSQWVT LEFPQLIRVS QLQIQFQGGF SSRRGCLEGS QGTQALHKIV DFYPEDNNSL QTFPIPAAEV DRLKVTFEDA TDFFGRVVIY HLRVLGEKV
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