About Regulator of DNA class I crossover intermediates 1
Regulator of DNA class I crossover intermediates 1 (REDIC1) is a protein
from Homo sapiens identified by UniProt accession
Q86WS4, 652 residues long.
MolForge cross-references it against 0 known binders and
15 disease associations.
Target properties
| Protein name | Regulator of DNA class I crossover intermediates 1 |
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| UniProt accession | Q86WS4 |
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| Gene | REDIC1 |
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| Organism | Homo sapiens |
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| Length | 652 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (15)
Diseases linked to this target (Open Targets).
- azoospermia · score 0.33
- Crohn's disease · score 0.03
- inflammatory bowel disease · score 0.03
- common variable immunodeficiency · score 0.02
- ulcerative colitis · score 0.02
- celiac disease · score 0.02
- juvenile idiopathic arthritis · score 0.02
- systemic lupus erythematosus · score 0.02
- psoriasis · score 0.02
- ankylosing spondylitis · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q86WS4-F1 | alphafold | PREDICTED | 43.20 | — |
Amino-acid sequence (652 residues)
MNWVGGSRSR VLIKQERRKQ KEYFEKHRLK SKMKSLGVLS PVKNSAVSLD ILNLYMVNQI SCKKKIPETV RKPTHVNMNR DIKMPLRKHN LELTMSPHCV PSKLCLDDTE TNVNCQRLSS KEDLGPVQSQ GMDSYSMLHP QFSKIENCSF TPSSFSVELP SNRHISKLNF TSGIAPTPQK LAYEKKQNDQ RSTVNCSDSL LSKLNKSQDV FSPSHKTTRF GTLFERLNSL GNRNLLTKSP AVIMDEDCRS TDEIRQSDYI TEKHSIQHIW GKNGKEVSNF LEDVNQSTPN LLSENCDSFV SQNMINVLNI DEQRIKKTFN KCDYDSMGDT CVVTSSDKNH VTDRCIRNIF TVPELTFSNS TLNKTSYPEK CQPNKKYQRE YNKNERNDLS TSFENDYYPS SSERKEKFEN DYQEKTPQKS IQKYPANSMG NIPSEELHSK QSWDFGLDEI LMEEGGIYSL KSKRISTKKI SLDSAQSSRS TSYSPRPTDS CFSSSSDLPS EDEDQISQQI EDSNRMTIKT KEKMNNFYVE RMAKLSGDRI VKNDDKIHKQ NENFYQFSVK NNTDQFPQLQ CNSAHILQNK TNDNCVLQAA RCDAGIQTES ESVMEEKLDV AIQCDLISKC TCRSDVSLCN LERCSGNIKA DTTGGQEIHK NN
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