Transmembrane protease serine 12 (TMPRSS12)

About Transmembrane protease serine 12

Transmembrane protease serine 12 (TMPRSS12) is a protein from Homo sapiens identified by UniProt accession Q86WS5, 348 residues long. MolForge cross-references it against 0 known binders and 96 disease associations.

Target properties

Protein name	Transmembrane protease serine 12
UniProt accession	Q86WS5
Gene	TMPRSS12
Organism	Homo sapiens
Length	348 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q86WS5-F1	alphafold	PREDICTED	80.66	—

Amino-acid sequence (348 residues)

MRLGLLSVAL LFVGSSHLYS DHYSPSGRHR LGPSPEPAAS SQQAEAVRKR LRRRREGGAH AEDCGTAPLK DVLQGSRIIG GTEAQAGAWP WVVSLQIKYG RVLVHVCGGT LVRERWVLTA AHCTKDASDP LMWTAVIGTN NIHGRYPHTK KIKIKAIIIH PNFILESYVN DIALFHLKKA VRYNDYIQPI CLPFDVFQIL DGNTKCFISG WGRTKEEGNA TNILQDAEVH YISREMCNSE RSYGGIIPNT SFCAGDEDGA FDTCRGDSGG PLMCYLPEYK RFFVMGITSY GHGCGRRGFP GVYIGPSFYQ KWLTEHFFHA STQGILTINI LRGQILIALC FVILLATT

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards