About D-lactate dehydrogenase, mitochondrial
D-lactate dehydrogenase, mitochondrial (LDHD) is a protein
from Homo sapiens identified by UniProt accession
Q86WU2, 507 residues long.
MolForge cross-references it against 0 known binders and
47 disease associations.
Target properties
| Protein name | D-lactate dehydrogenase, mitochondrial |
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| UniProt accession | Q86WU2 |
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| Gene | LDHD |
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| Organism | Homo sapiens |
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| Length | 507 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (47)
Diseases linked to this target (Open Targets).
- lactic aciduria due to D-lactic acid · score 0.64
- BMI-adjusted waist circumference · score 0.19
- Abnormal circulating lactate dehydrogenase concentration · score 0.14
- lymphocyte count · score 0.08
- hepatocellular carcinoma · score 0.08
- body height · score 0.07
- esophageal squamous cell carcinoma · score 0.07
- lung adenocarcinoma · score 0.07
- high density lipoprotein cholesterol measurement · score 0.06
- vital capacity · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q86WU2-F1 | alphafold | PREDICTED | 89.77 | — |
Amino-acid sequence (507 residues)
MARLLRSATW ELFPWRGYCS QKAKGELCRD FVEALKAVVG GSHVSTAAVV REQHGRDESV HRCEPPDAVV WPQNVEQVSR LAALCYRQGV PIIPFGTGTG LEGGVCAVQG GVCVNLTHMD RILELNQEDF SVVVEPGVTR KALNAHLRDS GLWFPVDPGA DASLCGMAAT GASGTNAVRY GTMRDNVLNL EVVLPDGRLL HTAGRGRHFR FGFWPEIPHH TAWYSPCVSL GRRKSAAGYN LTGLFVGSEG TLGLITATTL RLHPAPEATV AATCAFPSVQ AAVDSTVHIL QAAVPVARIE FLDEVMMDAC NRYSKLNCLV APTLFLEFHG SQQALEEQLQ RTEEIVQQNG ASDFSWAKEA EERSRLWTAR HNAWYAALAT RPGCKGYSTD VCVPISRLPE IVVQTKEDLN ASGLTGSIVG HVGDGNFHCI LLVNPDDAEE LGRVKAFAEQ LGRRALALHG TCTGEHGIGM GKRQLLQEEV GAVGVETMRQ LKAVLDPQGL MNPGKVL
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