Src kinase-associated phosphoprotein 1 (SKAP1)

About Src kinase-associated phosphoprotein 1

Src kinase-associated phosphoprotein 1 (SKAP1) is a protein from Homo sapiens identified by UniProt accession Q86WV1, 359 residues long. MolForge cross-references it against 0 known binders and 103 disease associations.

Target properties

Protein name	Src kinase-associated phosphoprotein 1
UniProt accession	Q86WV1
Gene	SKAP1
Organism	Homo sapiens
Length	359 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (103)

Diseases linked to this target (Open Targets).

ovarian carcinoma · score 0.39
ovarian serous carcinoma · score 0.35
systolic blood pressure · score 0.30
hair colour measurement · score 0.30
platelet count · score 0.29
malignant epithelial tumor of ovary · score 0.26
low density lipoprotein cholesterol measurement · score 0.25
red blood cell density measurement · score 0.25
prostate carcinoma · score 0.25
FEV/FVC ratio · score 0.24

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q86WV1-F1	alphafold	PREDICTED	69.57	—

Amino-acid sequence (359 residues)

MQAAALPEEI RWLLEDAEEF LAEGLRNENL SAVARDHRDH ILRGFQQIKA RYYWDFQPQG GDIGQDSSDD NHSGTLGLSL TSDAPFLSDY QDEGMEDIVK GAQELDNVIK QGYLEKKSKD HSFFGSEWQK RWCVVSRGLF YYYANEKSKQ PKGTFLIKGY GVRMAPHLRR DSKKESCFEL TSQDRRSYEF TATSPAEARD WVDQISFLLK DLSSLTIPYE EDEEEEEKEE TYDDIDGFDS PSCGSQCRPT ILPGSVGIKE PTEEKEEEDI YEVLPDEEHD LEEDESGTRR KGVDYASYYQ GLWDCHGDQP DELSFQRGDL IRILSKEYNM YGWWVGELNS LVGIVPKEYL TTAFEVEER

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards