Stimulator of interferon genes protein (STING1)

About Stimulator of interferon genes protein

Stimulator of interferon genes protein (STING1) is a protein from Homo sapiens identified by UniProt accession Q86WV6, 379 residues long. MolForge cross-references it against 0 known binders and 861 disease associations.

Target properties

Protein name	Stimulator of interferon genes protein
UniProt accession	Q86WV6
Gene	STING1
Organism	Homo sapiens
Length	379 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (861)

Diseases linked to this target (Open Targets).

STING-associated vasculopathy with onset in infancy · score 0.72
COVID-19 · score 0.48
familial chilblain lupus · score 0.37
severe acute respiratory syndrome · score 0.37
anti-merkel cell virus antibody measurement · score 0.24
merkel cell virus seropositivity · score 0.23
esophageal squamous cell carcinoma · score 0.22
autoinflammatory syndrome · score 0.19
genetic disorder · score 0.19
monocyte percentage of leukocytes · score 0.15

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q86WV6-F1	alphafold	PREDICTED	83.74	—

Amino-acid sequence (379 residues)

MPHSSLHPSI PCPRGHGAQK AALVLLSACL VTLWGLGEPP EHTLRYLVLH LASLQLGLLL NGVCSLAEEL RHIHSRYRGS YWRTVRACLG CPLRRGALLL LSIYFYYSLP NAVGPPFTWM LALLGLSQAL NILLGLKGLA PAEISAVCEK GNFNVAHGLA WSYYIGYLRL ILPELQARIR TYNQHYNNLL RGAVSQRLYI LLPLDCGVPD NLSMADPNIR FLDKLPQQTG DHAGIKDRVY SNSIYELLEN GQRAGTCVLE YATPLQTLFA MSQYSQAGFS REDRLEQAKL FCRTLEDILA DAPESQNNCR LIAYQEPADD SSFSLSQEVL RHLRQEEKEE VTVGSLKTSA VPSTSTMSQE PELLISGMEK PLPLRTDFS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards