About Cytochrome c oxidase assembly factor 5
Cytochrome c oxidase assembly factor 5 (COA5) is a protein
from Homo sapiens identified by UniProt accession
Q86WW8, 74 residues long.
MolForge cross-references it against 0 known binders and
26 disease associations.
Target properties
| Protein name | Cytochrome c oxidase assembly factor 5 |
|---|
| UniProt accession | Q86WW8 |
|---|
| Gene | COA5 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 74 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (26)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.54
- fatal infantile encephalocardiomyopathy · score 0.45
- cytochrome-c oxidase deficiency disease · score 0.37
- creatinine measurement · score 0.11
- neuritic plaque measurement · score 0.05
- Testicular regression syndrome · score 0.05
- congenital adrenal hyperplasia due to cytochrome P450 oxidoreductase deficiency · score 0.04
- congenital lipoid adrenal hyperplasia due to STAR deficency · score 0.04
- 46,XX ovotesticular disorder of sex development · score 0.04
- testicular agenesis · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q86WW8-F1 | alphafold | PREDICTED | 83.09 | — |
Amino-acid sequence (74 residues)
MPKYYEDKPQ GGACAGLKED LGACLLQSDC VVQEGKSPRQ CLKEGYCNSL KYAFFECKRS VLDNRARFRG RKGY
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