Active regulator of SIRT1 (RPS19BP1)

About Active regulator of SIRT1

Active regulator of SIRT1 (RPS19BP1) is a protein from Homo sapiens identified by UniProt accession Q86WX3, 136 residues long. MolForge cross-references it against 0 known binders and 42 disease associations.

Target properties

Protein name	Active regulator of SIRT1
UniProt accession	Q86WX3
Gene	RPS19BP1
Organism	Homo sapiens
Length	136 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (42)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.41
low grade glioma · score 0.17
protein measurement · score 0.13
mean corpuscular hemoglobin concentration · score 0.12
mean corpuscular volume · score 0.11
mean corpuscular hemoglobin · score 0.09
neoplasm · score 0.08
hepatocellular carcinoma · score 0.07
Immature Reticulocyte Fraction Measurement · score 0.07
reticulocyte measurement · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q86WX3-F1	alphafold	PREDICTED	73.80	—

Amino-acid sequence (136 residues)

MSAALLRRGL ELLAASEAPR DPPGQAKPRG APVKRPRKTK AIQAQKLRNS AKGKVPKSAL DEYRKRECRD HLRVNLKFLT RTRSTVAESV SQQILRQNRG RKACDRPVAK TKKKKAEGTV FTEEDFQKFQ QEYFGS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards