About HEAT repeat-containing protein 4
HEAT repeat-containing protein 4 (HEATR4) is a protein
from Homo sapiens identified by UniProt accession
Q86WZ0, 1026 residues long.
MolForge cross-references it against 0 known binders and
18 disease associations.
Target properties
| Protein name | HEAT repeat-containing protein 4 |
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| UniProt accession | Q86WZ0 |
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| Gene | HEATR4 |
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| Organism | Homo sapiens |
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| Length | 1026 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (18)
Diseases linked to this target (Open Targets).
- Generalized hypotonia · score 0.33
- platelet count · score 0.29
- blood metabolite measurement · score 0.26
- blood protein measurement · score 0.21
- glomerular filtration rate · score 0.18
- platelet crit · score 0.17
- self reported educational attainment · score 0.15
- phosphatidylcholine measurement · score 0.14
- cognitive function measurement · score 0.11
- urinary metabolite measurement · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q86WZ0-F1 | alphafold | PREDICTED | 65.49 | — |
Amino-acid sequence (1026 residues)
MTRTQKGKTF LPHCFYQSLP PRLGWGMILN YSKLKGKEEC ASVSSVPMVF FSSQYRLHRK SQYLKMAAAN LTFSQEVVWQ RGLPSIPYSQ YSFDHLYNTN DIIHTPQIRK ARPQKPVSFK FLGSSSPLTG DTSLAVKTES SANPEKKLKK SKPASTVREA PRPLIHHPCM HPDMLGRPPS LDVNLEEREA WLLPPEKEAR AWEATVLEKL NERTARWIQS KRPRRPGASP NKWQSFLRQQ YDWSHIRDEL TSASDLELLK QLEAEETAEF EDQSVILPPQ EKKKPELLLP VYYRLPSYFQ QAETVEIMPG NKSTEDIHEK TSLSQPQTQS YFRQVTPRAG KFAYSTDNTF EQEIYFDEVQ IIHQIGAKRD QIVLENLNRY NKQLSKVFPE TPEKWSAQAI PEASYRPVQG ALRWTALPTP AKDMLLQVGE KDVPIKTRRL KKQAKSLQED VTWELVVLRR MLKEWKTAWA LIIEWHHETV ENLLQSLGDL HDDVRIKAIT TCATAALERP RIATSQRDSD KTIQDLPEVL LPALEAALCD KNAHVRMAAA ICQYAIQSHN PLARNIMQTA LLKGNSVDSW AAAQCLALEG TATYPVIKRI LHQLFTKKNE DTEEQSYILL SYLSEKTTLI HTMLAVELNS CQWKNRIVAC QAFSRISGNV CLDMKHKLIQ LMWNDWNKEV RRAAAQALGQ MSLGKEVHDI IRVKLGQGNS QERVEALYLI GELKLMTAKL LPSFLHCFSD DFTAVRRAAC LAAGALQIRD KMVLECLLNL MQRDPYWKIK AFAIRALGQI GQVSPELTDL LLWAIHYEES PGVRLEACRS ILALKLQGDR VRDTFLDVLL LENHDAVLKE MYQTMKILNL GNEGNQEMLQ EIKNRIKTLS QKDLLTHKIL KLEMVMGKVR EEAKRVYLKP KGEQGPLTLQ TLLQETFQDE MVLPRRPSEV CDTEAVIKPV KPRAPNPWLQ SSVPGLTTRS KVRSSLVKDL RTSPEKRIAV GPFRSDYPAL YLGKFSERTF FSPIMSSPSG KKGAHL
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