Cerebellar degeneration-related protein 2-like (CDR2L)

About Cerebellar degeneration-related protein 2-like

Cerebellar degeneration-related protein 2-like (CDR2L) is a protein from Homo sapiens identified by UniProt accession Q86X02, 465 residues long. MolForge cross-references it against 0 known binders and 17 disease associations.

Target properties

Protein name	Cerebellar degeneration-related protein 2-like
UniProt accession	Q86X02
Gene	CDR2L
Organism	Homo sapiens
Length	465 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (17)

Diseases linked to this target (Open Targets).

hepatocellular carcinoma · score 0.03
neutrophil percentage of leukocytes · score 0.03
lymphocyte percentage of leukocytes · score 0.02
cancer · score 0.02
neoplasm · score 0.02
Tetralogy of Fallot · score 0.01
ulcerative colitis · score 0.01
calf circumference measurement · score 0.01
astrocytoma · score 0.00
Crohn's disease · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q86X02-F1	alphafold	PREDICTED	73.09	—

Amino-acid sequence (465 residues)

MRRAAGMEDF SAEEEESWYD QQDLEQDLHL AAELGKTLLE RNKELEGSLQ QMYSTNEEQV QEIEYLTKQL DTLRHVNEQH AKVYEQLDLT ARDLELTNHR LVLESKAAQQ KIHGLTETIE RLQAQVEELQ AQVEQLRGLE QLRVLREKRE RRRTIHTFPC LKELCTSPRC KDAFRLHSSS LELGPRPLEQ ENERLQTLVG ALRSQVSQER QRKERAEREY TAVLQEYSEL ERQLCEMEAC RLRVQELEAE LLELQQMKQA KTYLLGPDDH LAEALLAPLT QAPEADDPQP GRGDDLGAQD GVSSPAASPG HVVRKSCSDT ALNAIVAKDP ASRHAGNLTL HANSVRKRGM SILREVDEQY HALLEKYEEL LSKCRQHGAG VRHAGVQTSR PISRDSSWRD LRGGEEGQGE VKAGEKSLSQ HVEAVDKRLE QSQPEYKALF KEIFSRIQKT KADINATKVK THSSK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards