About Ral GTPase-activating protein subunit beta
Ral GTPase-activating protein subunit beta (RALGAPB) is a protein
from Homo sapiens identified by UniProt accession
Q86X10, 1494 residues long.
MolForge cross-references it against 0 known binders and
33 disease associations.
Target properties
| Protein name | Ral GTPase-activating protein subunit beta |
|---|
| UniProt accession | Q86X10 |
|---|
| Gene | RALGAPB |
|---|
| Organism | Homo sapiens |
|---|
| Length | 1494 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (33)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.52
- Intellectual disability · score 0.34
- Septo-optic dysplasia · score 0.27
- septooptic dysplasia · score 0.27
- squamous cell lung carcinoma · score 0.12
- Myopia · score 0.11
- pathological myopia · score 0.11
- peak expiratory flow · score 0.10
- head and neck squamous cell carcinoma · score 0.09
- FEV change measurement · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q86X10-F1 | alphafold | PREDICTED | 74.66 | — |
Amino-acid sequence (1494 residues)
MYSEWRSLHL VIQNDQGHTS VLHSYPESVG REVANAVVRP LGQVLGTPSV AGSENLLKTD KEVKWTMEVI CYGLTLPLDG ETVKYCVDVY TDWIMALVLP KDSIPLPVIK EPNQYVQTIL KHLQNLFVPR QEQGSSQIRL CLQVLRAIQK LARESSLMAR ETWEVLLLFL LQINDILLAP PTVQGGIAEN LAEKLIGVLF EVWLLACTRC FPTPPYWKTA KEMVANWRHH PAVVEQWSKV ICALTSRLLR FTYGPSFPAF KVPDEDASLI PPEMDNECVA QTWFRFLHML SNPVDLSNPA IISSTPKFQE QFLNVSGMPQ ELNQYPCLKH LPQIFFRAMR GISCLVDAFL GISRPRSDSA PPTPVNRLSM PQSAAVSTTP PHNRRHRAVT VNKATMKTST VSTAHASKVQ HQTSSTSPLS SPNQTSSEPR PLPAPRRPKV NSILNLFGSW LFDAAFVHCK LHNGINRDSS MTAITTQASM EFRRKGSQMS TDTMVSNPMF DASEFPDNYE AGRAEACGTL CRIFCSKKTG EEILPAYLSR FYMLLIQGLQ INDYVCHPVL ASVILNSPPL FCCDLKGIDV VVPYFISALE TILPDRELSK FKSYVNPTEL RRSSINILLS LLPLPHHFGT VKSEVVLEGK FSNDDSSSYD KPITFLSLKL RLVNILIGAL QTETDPNNTQ MILGAMLNIV QDSALLEAIG CQMEMGGGEN NLKSHSRTNS GISSASGGST EPTTPDSERP AQALLRDYAL NTDSAAGLLI RSIHLVTQRL NSQWRQDMSI SLAALELLSG LAKVKVMVDS GDRKRAISSV CTYIVYQCSR PAPLHSRDLH SMIVAAFQCL CVWLTEHPDM LDEKDCLKEV LEIVELGISG SKSKNNEQEV KYKGDKEPNP ASMRVKDAAE ATLTCIMQLL GAFPSPSGPA SPCSLVNETT LIKYSRLPTI NKHSFRYFVL DNSVILAMLE QPLGNEQNDF FPSVTVLVRG MSGRLAWAQQ LCLLPRGAKA NQKLFVPEPR PVPKNDVGFK YSVKHRPFPE EVDKIPFVKA DLSIPDLHEI VTEELEERHE KLRSGMAQQI AYEIHLEQQS EEELQKRSFP DPVTDCKPPP PAQEFQTARL FLSHFGFLSL EALKEPANSR LPPHLIALDS TIPGFFDDIG YLDLLPCRPF DTVFIFYMKP GQKTNQEILK NVESSRTVQP HFLEFLLSLG WSVDVGRHPG WTGHVSTSWS INCCDDGEGS QQEVISSEDI GASIFNGQKK VLYYADALTE IAFVVPSPVE SLTDSLESNI SDQDSDSNMD LMPGILKQPS LTLELFPNHT DNLNSSQRLS PSSRMRKLPQ GRPVPPLGPE TRVSVVWVER YDDIENFPLS ELMTEISTGV ETTANSSTSL RSTTLEKEVP VIFIHPLNTG LFRIKIQGAT GKFNMVIPLV DGMIVSRRAL GFLVRQTVIN ICRRKRLESD SYSPPHVRRK QKITDIVNKY RNKQLEPEFY TSLFQEVGLK NCSS
Explore Ral GTPase-activating protein subunit beta with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets