HORMA domain-containing protein 1 (HORMAD1)

About HORMA domain-containing protein 1

HORMA domain-containing protein 1 (HORMAD1) is a protein from Homo sapiens identified by UniProt accession Q86X24, 394 residues long. MolForge cross-references it against 0 known binders and 200 disease associations.

Target properties

Protein name	HORMA domain-containing protein 1
UniProt accession	Q86X24
Gene	HORMAD1
Organism	Homo sapiens
Length	394 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (200)

Diseases linked to this target (Open Targets).

male infertility · score 0.34
lymphocyte count · score 0.25
inflammatory bowel disease · score 0.25
eosinophil count · score 0.24
neutrophil percentage of leukocytes · score 0.19
urate measurement · score 0.18
leukocyte count · score 0.17
blood protein measurement · score 0.14
sitting height measurement · score 0.14
platelet count · score 0.14

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q86X24-F1	alphafold	PREDICTED	65.64	—

Amino-acid sequence (394 residues)

MATAQLQRTP MSALVFPNKI STEHQSLVLV KRLLAVSVSC ITYLRGIFPE CAYGTRYLDD LCVKILREDK NCPGSTQLVK WMLGCYDALQ KKYLRMVVLA VYTNPEDPQT ISECYQFKFK YTNNGPLMDF ISKNQSNESS MLSTDTKKAS ILLIRKIYIL MQNLGPLPND VCLTMKLFYY DEVTPPDYQP PGFKDGDCEG VIFEGEPMYL NVGEVSTPFH IFKVKVTTER ERMENIDSTI LSPKQIKTPF QKILRDKDVE DEQEHYTSDD LDIETKMEEQ EKNPASSELE EPSLVCEEDE IMRSKESPDL SISHSQVEQL VNKTSELDMS ESKTRSGKVF QNKMANGNQP VKSSKENRKR SQHESGRIVL HHFDSSSQES VPKRRKFSEP KEHI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards