About Ras-specific guanine nucleotide-releasing factor RalGPS2
Ras-specific guanine nucleotide-releasing factor RalGPS2 (RALGPS2) is a protein
from Homo sapiens identified by UniProt accession
Q86X27, 583 residues long.
MolForge cross-references it against 0 known binders and
41 disease associations.
Target properties
| Protein name | Ras-specific guanine nucleotide-releasing factor RalGPS2 |
|---|
| UniProt accession | Q86X27 |
|---|
| Gene | RALGPS2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 583 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (41)
Diseases linked to this target (Open Targets).
- vital capacity · score 0.36
- forced expiratory volume · score 0.34
- protein measurement · score 0.29
- alkaline phosphatase measurement · score 0.26
- neurodegenerative disease · score 0.26
- mean corpuscular hemoglobin concentration · score 0.26
- blood protein measurement · score 0.25
- mean corpuscular hemoglobin · score 0.25
- body height · score 0.23
- grip strength measurement · score 0.22
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q86X27-F1 | alphafold | PREDICTED | 71.22 | — |
Amino-acid sequence (583 residues)
MDLMNGQASS VNIAATASEK SSSSESLSDK GSELKKSFDA VVFDVLKVTP EEYAGQITLM DVPVFKAIQP DELSSCGWNK KEKYSSAPNA VAFTRRFNHV SFWVVREILH AQTLKIRAEV LSHYIKTAKK LYELNNLHAL MAVVSGLQSA PIFRLTKTWA LLSRKDKTTF EKLEYVMSKE DNYKRLRDYI SSLKMTPCIP YLGIYLSDLT YIDSAYPSTG SILENEQRSN LMNNILRIIS DLQQSCEYDI PMLPHVQKYL NSVQYIEELQ KFVEDDNYKL SLKIEPGTST PRSAASREDL VGPEVGASPQ SGRKSVAAEG ALLPQTPPSP RNLIPHGHRK CHSLGYNFIH KMNTAEFKSA TFPNAGPRHL LDDSVMEPHA PSRGQAESST LSSGISIGSS DGSELSEETS WPAFERNRLY HSLGPVTRVA RNGYRSHMKA SSSAESEDLA VHLYPGAVTI QGVLRRKTLL KEGKKPTVAS WTKYWAALCG TQLFYYAAKS LKATERKHFK STSNKNVSVI GWMVMMADDP EHPDLFLLTD SEKGNSYKFQ AGNRMNAMLW FKHLSAACQS NKQQVPTNLM TFE
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