Leucine-rich repeat-containing protein 28 (LRRC28)

About Leucine-rich repeat-containing protein 28

Leucine-rich repeat-containing protein 28 (LRRC28) is a protein from Homo sapiens identified by UniProt accession Q86X40, 367 residues long. MolForge cross-references it against 0 known binders and 19 disease associations.

Target properties

Protein name	Leucine-rich repeat-containing protein 28
UniProt accession	Q86X40
Gene	LRRC28
Organism	Homo sapiens
Length	367 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (19)

Diseases linked to this target (Open Targets).

FEV/FVC ratio · score 0.41
neurodegenerative disease · score 0.21
gestational age · score 0.11
parental genotype effect measurement · score 0.11
hemoglobin measurement · score 0.09
hematocrit · score 0.08
red blood cell density measurement · score 0.07
mean corpuscular hemoglobin concentration · score 0.07
erythrocyte count · score 0.07
Varicose veins · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q86X40-F1	alphafold	PREDICTED	90.22	—

Amino-acid sequence (367 residues)

MASELCKTIS VARLEKHKNL FLNYRNLHHF PLELLKDEGL QYLERLYMKR NSLTSLPENL AQKLPNLVEL YLHSNNIVVV PEAIGSLVKL QCLDLSDNAL EIVCPEIGRL RALRHLRLAN NQLQFLPPEV GDLKELQTLD ISTNRLLTLP ERLHMCLSLQ YLTVDRNRLW YVPRHLCQLP SLNELSMAGN RLAFLPLDLG RSRELQYVYV DNNIHLKGLP SYLYNKVIGC SGCGAPIQVS EVKLLSFSSG QRTVFLPAEV KAIGTEHDHV LPLQELAMRG LYHTYHSLLK DLNFLSPISL PRSLLELLHC PLGHCHRCSE PMFTIVYPKL FPLRETPMAG LHQWKTTVSF VAYCCSTQCL QTFDLLS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards