Dynein axonemal assembly factor 11 (DNAAF11)

About Dynein axonemal assembly factor 11

Dynein axonemal assembly factor 11 (DNAAF11) is a protein from Homo sapiens identified by UniProt accession Q86X45, 466 residues long. MolForge cross-references it against 0 known binders and 44 disease associations.

Target properties

Protein name	Dynein axonemal assembly factor 11
UniProt accession	Q86X45
Gene	DNAAF11
Organism	Homo sapiens
Length	466 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (44)

Diseases linked to this target (Open Targets).

primary ciliary dyskinesia · score 0.73
Heterotaxy · score 0.33
cognitive function measurement · score 0.31
adolescent idiopathic scoliosis · score 0.30
smoking status measurement · score 0.15
smoking initiation · score 0.15
self reported educational attainment · score 0.14
infertility · score 0.11
hypothyroidism · score 0.07
appendicular lean mass · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q86X45-F1	alphafold	PREDICTED	74.33	—

Amino-acid sequence (466 residues)

MGWITEDLIR RNAEHNDCVI FSLEELSLHQ QEIERLEHID KWCRDLKILY LQNNLIGKIE NVSKLKKLEY LNLALNNIEK IENLEGCEEL AKLDLTVNFI GELSSIKNLQ HNIHLKELFL MGNPCASFDH YREFVVATLP QLKWLDGKEI EPSERIKALQ DYSVIEPQIR EQEKDHCLKR AKLKEEAQRK HQEEDKNEDK RSNAGFDGRW YTDINATLSS LESKDHLQAP DTEEHNTKKL DNSEDDLEFW NKPCLFTPES RLETLRHMEK QRKKQEKLSE KKKKVKPPRT LITEDGKALN VNEPKIDFSL KDNEKQIILD LAVYRYMDTS LIDVDVQPTY VRVMIKGKPF QLVLPAEVKP DSSSAKRSQT TGHLVICMPK VGEVITGGQR AFKSMKTTSD RSREQTNTRS KHMEKLEVDP SKHSFPDVTN IVQEKKHTPR RRPEPKIIPS EEDPTFEDNP EVPPLI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards