About EZH inhibitory protein
EZH inhibitory protein (EZHIP) is a protein
from Homo sapiens identified by UniProt accession
Q86X51, 503 residues long.
MolForge cross-references it against 0 known binders and
46 disease associations.
Target properties
| Protein name | EZH inhibitory protein |
|---|
| UniProt accession | Q86X51 |
|---|
| Gene | EZHIP |
|---|
| Organism | Homo sapiens |
|---|
| Length | 503 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (46)
Diseases linked to this target (Open Targets).
- primary ovarian insufficiency · score 0.08
- 46,XX gonadal dysgenesis · score 0.06
- Perrault syndrome · score 0.06
- 46,XY complete gonadal dysgenesis · score 0.05
- ovarian dysgenesis 10 · score 0.05
- Perrault syndrome 2 · score 0.05
- primary hypergonadotropic hypogonadism-partial alopecia syndrome · score 0.05
- Primary hypergonadotropic hypogonadism - partial alopecia · score 0.05
- 46,XX testicular disorder of sex development · score 0.05
- premature ovarian failure 18 · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q86X51-F1 | alphafold | PREDICTED | 48.82 | — |
Amino-acid sequence (503 residues)
MATQSDMEKE QKHQQDEGQG GLNNETALAS GDACGTGNQD PAASVTTVSS QASPSGGAAL SSSTAGSSAA AATSAAIFIT DEASGLPIIA AVLTERHSDR QDCRSPHEVF GCVVPEGGSQ AAVGPQKATG HADEHLAQTK SPGNSRRRKQ PCRNQAAPAQ KPPGRRLFPE PLPPSSPGFR PSSYPCSGAS TSSQATQPGP ALLSHASEAR PATRSRITLV ASALRRRASG PGPVIRGCTA QPGPAFPHRA THLDPARLSP ESAPGPARRG RASVPGPARR GCDSAPGPAR RGRDSAPVSA PRGRDSAPGS ARRGRDSAPG PALRVRTARS DAGHRSTSTT PGTGLRSRST QQRSALLSRR SLSGSADENP SCGTGSERLA FQSRSGSPDP EVPSRASPPV WHAVRMRASS PSPPGRFFLP IPQQWDESSS SSYASNSSSP SRSPGLSPSS PSPEFLGLRS ISTPSPESLR YALMPEFYAL SPVPPEEQAE IESTAHPATP PEP
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