About Histone-arginine methyltransferase CARM1
Histone-arginine methyltransferase CARM1 (CARM1) is a protein
from Homo sapiens identified by UniProt accession
Q86X55, 608 residues long.
MolForge cross-references it against 0 known binders and
242 disease associations.
Target properties
| Protein name | Histone-arginine methyltransferase CARM1 |
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| UniProt accession | Q86X55 |
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| Gene | CARM1 |
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| Organism | Homo sapiens |
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| Length | 608 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (242)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.49
- breast adenocarcinoma · score 0.27
- lysosomal storage disease · score 0.26
- glioblastoma multiforme · score 0.26
- endometrial cancer · score 0.25
- gastric adenocarcinoma · score 0.25
- urinary bladder cancer · score 0.24
- lung adenocarcinoma · score 0.24
- head and neck squamous cell carcinoma · score 0.23
- squamous cell lung carcinoma · score 0.23
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q86X55-F1 | alphafold | PREDICTED | 78.24 | — |
Amino-acid sequence (608 residues)
MAAAAAAVGP GAGGAGSAVP GGAGPCATVS VFPGARLLTI GDANGEIQRH AEQQALRLEV RAGPDSAGIA LYSHEDVCVF KCSVSRETEC SRVGKQSFII TLGCNSVLIQ FATPNDFCSF YNILKTCRGH TLERSVFSER TEESSAVQYF QFYGYLSQQQ NMMQDYVRTG TYQRAILQNH TDFKDKIVLD VGCGSGILSF FAAQAGARKI YAVEASTMAQ HAEVLVKSNN LTDRIVVIPG KVEEVSLPEQ VDIIISEPMG YMLFNERMLE SYLHAKKYLK PSGNMFPTIG DVHLAPFTDE QLYMEQFTKA NFWYQPSFHG VDLSALRGAA VDEYFRQPVV DTFDIRILMA KSVKYTVNFL EAKEGDLHRI EIPFKFHMLH SGLVHGLAFW FDVAFIGSIM TVWLSTAPTE PLTHWYQVRC LFQSPLFAKA GDTLSGTCLL IANKRQSYDI SIVAQVDQTG SKSSNLLDLK NPFFRYTGTT PSPPPGSHYT SPSENMWNTG STYNLSSGMA VAGMPTAYDL SSVIASGSSV GHNNLIPLAN TGIVNHTHSR MGSIMSTGIV QGSSGAQGSG GGSTSAHYAV NSQFTMGGPA ISMASPMSIP TNTMHYGS
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