Corepressor of RBPJ and splicing regulator (CIRSR)

About Corepressor of RBPJ and splicing regulator

Corepressor of RBPJ and splicing regulator (CIRSR) is a protein from Homo sapiens identified by UniProt accession Q86X95, 450 residues long. MolForge cross-references it against 0 known binders and 44 disease associations.

Target properties

Protein name	Corepressor of RBPJ and splicing regulator
UniProt accession	Q86X95
Gene	CIRSR
Organism	Homo sapiens
Length	450 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q86X95-F1	alphafold	PREDICTED	59.71	—

Amino-acid sequence (450 residues)

MGKSFANFMC KKDFHPASKS NIKKVWMAEQ KISYDKKKQE ELMQQYLKEQ ESYDNRLLMG DERVKNGLNF MYEAPPGAKK ENKEKEETEG ETEYKFEWQK GAPREKYAKD DMNIRDQPFG IQVRNVRCIK CHKWGHVNTD RECPLFGLSG INASSVPTDG SGPSMHPSEL IAEMRNSGFA LKRNVLGRNL TANDPSQEYV ASEGEEDPEV EFLKSLTTKQ KQKLLRKLDR LEKKKKKKDR KKKKFQKSRS KHKKHKSSSS SSSSSSSSSS TETSESSSES ESNNKEKKIQ RKKRKKNKCS GHNNSDSEEK DKSKKRKLHE ELSSSHHNRE KAKEKPRFLK HESSREDSKW SHSDSDKKSR THKHSPEKRG SERKEGSSRS HGREERSRRS RSRSPGSYKQ RETRKRAQRN PGEEQSRRND SRSHGTDLYR GEKMYREHPG GTHTKVTQRE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards