Histone-arginine methyltransferase METTL23 (METTL23)

About Histone-arginine methyltransferase METTL23

Histone-arginine methyltransferase METTL23 (METTL23) is a protein from Homo sapiens identified by UniProt accession Q86XA0, 190 residues long. MolForge cross-references it against 0 known binders and 43 disease associations.

Target properties

Protein name	Histone-arginine methyltransferase METTL23
UniProt accession	Q86XA0
Gene	METTL23
Organism	Homo sapiens
Length	190 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (43)

Diseases linked to this target (Open Targets).

autosomal recessive non-syndromic intellectual disability · score 0.63
genetic disorder · score 0.50
Intellectual disability · score 0.37
mathematical ability · score 0.13
neutrophil count · score 0.11
retinitis pigmentosa · score 0.07
alkaline phosphatase measurement · score 0.07
Leber congenital amaurosis · score 0.06
intellectual developmental disorder and retinitis pigmentosa; IDDRP · score 0.05
coloboma of optic nerve · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q86XA0-F1	alphafold	PREDICTED	93.87	—

Amino-acid sequence (190 residues)

MYVWPCAVVL AQYLWFHRRS LPGKAILEIG AGVSLPGILA AKCGAEVILS DSSELPHCLE VCRQSCQMNN LPHLQVVGLT WGHISWDLLA LPPQDIILAS DVFFEPEDFE DILATIYFLM HKNPKVQLWS TYQVRSADWS LEALLYKWDM KCVHIPLESF DADKEDIAES TLPGRHTVEM LVISFAKDSL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards