About Calcium uptake protein 3, mitochondrial
Calcium uptake protein 3, mitochondrial (MICU3) is a protein
from Homo sapiens identified by UniProt accession
Q86XE3, 530 residues long.
MolForge cross-references it against 0 known binders and
39 disease associations.
Target properties
| Protein name | Calcium uptake protein 3, mitochondrial |
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| UniProt accession | Q86XE3 |
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| Gene | MICU3 |
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| Organism | Homo sapiens |
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| Length | 530 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (39)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.45
- FEV/FVC ratio · score 0.41
- Parkinson disease · score 0.26
- PHF-tau measurement · score 0.25
- drug use measurement · score 0.15
- risk-taking behaviour · score 0.09
- visual perception measurement · score 0.06
- breast carcinoma · score 0.03
- self reported educational attainment · score 0.03
- glioblastoma multiforme · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q86XE3-F1 | alphafold | PREDICTED | 71.25 | — |
Amino-acid sequence (530 residues)
MAALRRLLWP PPRVSPPLCA HQPLLGPWGR PAVTTLGLPG RPFSSREDEE RAVAEAAWRR RRRWGELSVA AAAGGGLVGL VCYQLYGDPR AGSPATGRPS KSAATEPEDP PRGRGMLPIP VAAAKETVAI GRTDIEDLDL YATSRERRFR LFASIECEGQ LFMTPYDFIL AVTTDEPKVA KTWKSLSKQE LNQMLAETPP VWKGSSKLFR NLKEKGVISY TEYLFLLCIL TKPHAGFRIA FNMFDTDGNE MVDKKEFLVL QEIFRKKNEK REIKGDEEKR AMLRLQLYGY HSPTNSVLKT DAEELVSRSY WDTLRRNTSQ ALFSDLAERA DDITSLVTDT TLLVHFFGKK GKAELNFEDF YRFMDNLQTE VLEIEFLSYS NGMNTISEED FAHILLRYTN VENTSVFLEN VRYSIPEEKG ITFDEFRSFF QFLNNLEDFA IALNMYNFAS RSIGQDEFKR AVYVATGLKF SPHLVNTVFK IFDVDKDDQL SYKEFIGIMK DRLHRGFRGY KTVQKYPTFK SCLKKELHSR
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