About 4-hydroxy-2-oxoglutarate aldolase, mitochondrial
4-hydroxy-2-oxoglutarate aldolase, mitochondrial (HOGA1) is a protein
from Homo sapiens identified by UniProt accession
Q86XE5, 327 residues long.
MolForge cross-references it against 0 known binders and
65 disease associations.
Target properties
| Protein name | 4-hydroxy-2-oxoglutarate aldolase, mitochondrial |
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| UniProt accession | Q86XE5 |
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| Gene | HOGA1 |
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| Organism | Homo sapiens |
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| Length | 327 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (65)
Diseases linked to this target (Open Targets).
- primary hyperoxaluria type 3 · score 0.79
- primary hyperoxaluria · score 0.51
- neurodegenerative disease · score 0.28
- genetic disorder · score 0.19
- metabolite measurement · score 0.14
- protein measurement · score 0.12
- amino acid measurement · score 0.12
- blood metabolite measurement · score 0.12
- attention deficit hyperactivity disorder · score 0.08
- attention deficit-hyperactivity disorder 8 · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q86XE5-F1 | alphafold | PREDICTED | 92.68 | — |
Amino-acid sequence (327 residues)
MLGPQVWSSV RQGLSRSLSR NVGVWASGEG KKVDIAGIYP PVTTPFTATA EVDYGKLEEN LHKLGTFPFR GFVVQGSNGE FPFLTSSERL EVVSRVRQAM PKNRLLLAGS GCESTQATVE MTVSMAQVGA DAAMVVTPCY YRGRMSSAAL IHHYTKVADL SPIPVVLYSV PANTGLDLPV DAVVTLSQHP NIVGMKDSGG DVTRIGLIVH KTRKQDFQVL AGSAGFLMAS YALGAVGGVC ALANVLGAQV CQLERLCCTG QWEDAQKLQH RLIEPNAAVT RRFGIPGLKK IMDWFGYYGG PCRAPLQELS PAEEEALRMD FTSNGWL
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