About Dihydrofolate reductase 2, mitochondrial
Dihydrofolate reductase 2, mitochondrial (DHFR2) is a protein
from Homo sapiens identified by UniProt accession
Q86XF0, 187 residues long.
MolForge cross-references it against 0 known binders and
87 disease associations.
Target properties
| Protein name | Dihydrofolate reductase 2, mitochondrial |
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| UniProt accession | Q86XF0 |
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| Gene | DHFR2 |
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| Organism | Homo sapiens |
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| Length | 187 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (87)
Diseases linked to this target (Open Targets).
- body mass index · score 0.32
- body fat percentage · score 0.30
- lean body mass · score 0.30
- fat body mass · score 0.28
- body weight · score 0.26
- self reported educational attainment · score 0.25
- blood protein measurement · score 0.25
- age at first sexual intercourse measurement · score 0.24
- urate measurement · score 0.24
- mathematical ability · score 0.23
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q86XF0-F1 | alphafold | PREDICTED | 96.05 | — |
Amino-acid sequence (187 residues)
MFLLLNCIVA VSQNMGIGKN GDLPRPPLRN EFRYFQRMTT TSSVEGKQNL VIMGRKTWFS IPEKNRPLKD RINLVLSREL KEPPQGAHFL ARSLDDALKL TERPELANKV DMIWIVGGSS VYKEAMNHLG HLKLFVTRIM QDFESDTFFS EIDLEKYKLL PEYPGVLSDV QEGKHIKYKF EVCEKDD
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