About Calcium homeostasis modulator protein 3
Calcium homeostasis modulator protein 3 (CALHM3) is a protein
from Homo sapiens identified by UniProt accession
Q86XJ0, 344 residues long.
MolForge cross-references it against 0 known binders and
16 disease associations.
Target properties
| Protein name | Calcium homeostasis modulator protein 3 |
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| UniProt accession | Q86XJ0 |
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| Gene | CALHM3 |
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| Organism | Homo sapiens |
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| Length | 344 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (16)
Diseases linked to this target (Open Targets).
- self reported educational attainment · score 0.24
- atrial fibrillation · score 0.07
- atrial flutter · score 0.06
- cardiac arrhythmia · score 0.05
- cardiac edema · score 0.05
- white matter microstructure measurement · score 0.04
- diastolic blood pressure · score 0.04
- FEV/FVC ratio · score 0.04
- rheumatoid arthritis · score 0.04
- total blood protein measurement · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q86XJ0-F1 | alphafold | PREDICTED | 79.24 | — |
Amino-acid sequence (344 residues)
MDKFRMLFQH FQSSSESVMN GICLLLAAVT VKLYSSFDFN CPCLVHYNAL YGLGLLLTPP LALFLCGLLA NRQSVVMVEE WRRPAGHRRK DPGIIRYMCS SVLQRALAAP LVWILLALLD GKCFVCAFSS SVDPEKFLDF ANMTPSQVQL FLAKVPCKED ELVRDSPARK AVSRYLRCLS QAIGWSVTLL LIIAAFLARC LRPCFDQTVF LQRRYWSNYV DLEQKLFDET CCEHARDFAH RCVLHFFASM RSELQARGLR RGNAGRRLEL PAVPEPPEGL DSGSGKAHLR AISSREQVDR LLSTWYSSKP PLDLAASPGL CGGGLSHRAP TLALGTRLSQ HTDV
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