About Swi5-dependent recombination DNA repair protein 1 homolog
Swi5-dependent recombination DNA repair protein 1 homolog (SFR1) is a protein
from Homo sapiens identified by UniProt accession
Q86XK3, 245 residues long.
MolForge cross-references it against 0 known binders and
15 disease associations.
Target properties
| Protein name | Swi5-dependent recombination DNA repair protein 1 homolog |
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| UniProt accession | Q86XK3 |
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| Gene | SFR1 |
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| Organism | Homo sapiens |
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| Length | 245 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (15)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.21
- isolated asymptomatic elevation of creatine phosphokinase · score 0.07
- pentosuria · score 0.05
- breast cancer · score 0.04
- cardiac hypertrophy · score 0.04
- isolated spina bifida · score 0.04
- diastolic blood pressure · score 0.02
- cancer · score 0.02
- autoimmune disease · score 0.00
- endometrium adenocarcinoma · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q86XK3-F1 | alphafold | PREDICTED | 66.91 | — |
Amino-acid sequence (245 residues)
MAEGEKNQDF TFKMESPSDS AVVLPSTPQA SANPSSPYTN SSRKQPMSAT LRERLRKTRF SFNSSYNVVK RLKVESEEND QTFSEKPASS TEENCLEFQE SFKHIDSEFE ENTNLKNTLK NLNVCESQSL DSGSCSALQN EFVSEKLPKQ RLNAEKAKLV KQVQEKEDLL RRLKLVKMYR SKNDLSQLQL LIKKWRSCSQ LLLYELQSAV SEENKKLSLT QLIDHYGLDD KLLHYNRSEE EFIDV
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