V-set and immunoglobulin domain-containing protein…

About V-set and immunoglobulin domain-containing protein 1

V-set and immunoglobulin domain-containing protein 1 (VSIG1) is a protein from Homo sapiens identified by UniProt accession Q86XK7, 387 residues long. MolForge cross-references it against 0 known binders and 53 disease associations.

Target properties

Protein name	V-set and immunoglobulin domain-containing protein 1
UniProt accession	Q86XK7
Gene	VSIG1
Organism	Homo sapiens
Length	387 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (53)

Diseases linked to this target (Open Targets).

Barrett's esophagus · score 0.07
MALT lymphoma · score 0.06
esophageal adenocarcinoma · score 0.06
gonorrhea · score 0.05
cancer · score 0.05
neoplasm · score 0.05
sessile serrated polyp · score 0.04
CDH1-related diffuse gastric and lobular breast cancer syndrome · score 0.04
Colon Sessile Serrated Adenoma/Polyp · score 0.04
gastrointestinal stromal tumor · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q86XK7-F1	alphafold	PREDICTED	75.62	—

Amino-acid sequence (387 residues)

MVFAFWKVFL ILSCLAGQVS VVQVTIPDGF VNVTVGSNVT LICIYTTTVA SREQLSIQWS FFHKKEMEPI SIYFSQGGQA VAIGQFKDRI TGSNDPGNAS ITISHMQPAD SGIYICDVNN PPDFLGQNQG ILNVSVLVKP SKPLCSVQGR PETGHTISLS CLSALGTPSP VYYWHKLEGR DIVPVKENFN PTTGILVIGN LTNFEQGYYQ CTAINRLGNS SCEIDLTSSH PEVGIIVGAL IGSLVGAAII ISVVCFARNK AKAKAKERNS KTIAELEPMT KINPRGESEA MPREDATQLE VTLPSSIHET GPDTIQEPDY EPKPTQEPAP EPAPGSEPMA VPDLDIELEL EPETQSELEP EPEPEPESEP GVVVEPLSED EKGVVKA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

V-set and immunoglobulin domain-containing protein 1 (VSIG1)