About Proline-rich membrane anchor 1
Proline-rich membrane anchor 1 (PRIMA1) is a protein
from Homo sapiens identified by UniProt accession
Q86XR5, 153 residues long.
MolForge cross-references it against 0 known binders and
84 disease associations.
Target properties
| Protein name | Proline-rich membrane anchor 1 |
|---|
| UniProt accession | Q86XR5 |
|---|
| Gene | PRIMA1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 153 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (84)
Diseases linked to this target (Open Targets).
- sleep-related hypermotor epilepsy · score 0.47
- sleep duration · score 0.33
- PHF-tau measurement · score 0.32
- self reported educational attainment · score 0.28
- vital capacity · score 0.25
- lifestyle measurement · score 0.23
- body mass index · score 0.19
- body fat percentage · score 0.09
- antisocial behaviour measurement · score 0.07
- attention deficit hyperactivity disorder · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q86XR5-F1 | alphafold | PREDICTED | 63.58 | — |
Amino-acid sequence (153 residues)
MLLRDLVLRR GCCWSSLLLH CALHPLWGFV QVTHGEPQKS CSKVTDSCRH VCQCRPPPPL PPPPPPPPPP RLLSAPAPNS TSCPTEESWW SGLVIIIAVC CASLVFLTVL VIICYKAIKR KPLRKDENGT SVAEYPMSAS QSNKGVDVNN AVV
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