About TIR domain-containing adapter molecule 2
TIR domain-containing adapter molecule 2 (TICAM2) is a protein
from Homo sapiens identified by UniProt accession
Q86XR7, 235 residues long.
MolForge cross-references it against 0 known binders and
21 disease associations.
Target properties
| Protein name | TIR domain-containing adapter molecule 2 |
|---|
| UniProt accession | Q86XR7 |
|---|
| Gene | TICAM2 |
|---|
| Organism | Homo sapiens |
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| Length | 235 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (21)
Diseases linked to this target (Open Targets).
- lung adenocarcinoma · score 0.27
- breast adenocarcinoma · score 0.24
- head and neck squamous cell carcinoma · score 0.23
- cutaneous melanoma · score 0.16
- body height · score 0.15
- gastric adenocarcinoma · score 0.13
- forced expiratory volume · score 0.13
- vital capacity · score 0.12
- sitting height measurement · score 0.08
- BMI-adjusted waist circumference · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q86XR7-F1 | alphafold | PREDICTED | 74.38 | — |
Amino-acid sequence (235 residues)
MGIGKSKINS CPLSLSWGKR HSVDTSPGYH ESDSKKSEDL SLCNVAEHSN TTEGPTGKQE GAQSVEEMFE EEAEEEVFLK FVILHAEDDT DEALRVQNLL QDDFGIKPGI IFAEMPCGRQ HLQNLDDAVN GSAWTILLLT ENFLRDTWCN FQFYTSLMNS VNRQHKYNSV IPMRPLNNPL PRERTPFALQ TINALEEESR GFPTQVERIF QESVYKTQQT IWKETRNMVQ RQFIA
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