Centrosomal protein of 57 kDa (CEP57)

About Centrosomal protein of 57 kDa

Centrosomal protein of 57 kDa (CEP57) is a protein from Homo sapiens identified by UniProt accession Q86XR8, 500 residues long. MolForge cross-references it against 0 known binders and 91 disease associations.

Target properties

Protein name	Centrosomal protein of 57 kDa
UniProt accession	Q86XR8
Gene	CEP57
Organism	Homo sapiens
Length	500 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (91)

Diseases linked to this target (Open Targets).

mosaic variegated aneuploidy syndrome · score 0.78
neurodegenerative disease · score 0.51
self reported educational attainment · score 0.32
Red cell distribution width · score 0.32
mean corpuscular volume · score 0.30
intelligence · score 0.29
cognitive function measurement · score 0.28
appendicular lean mass · score 0.28
mean corpuscular hemoglobin concentration · score 0.28
mean corpuscular hemoglobin · score 0.28

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q86XR8-F1	alphafold	PREDICTED	75.31	—

Amino-acid sequence (500 residues)

MAAASVSAAS GSHLSNSFAE PSRSNGSMVR HSSSPYVVYP SDKPFLNSDL RRSPSKPTLA YPESNSRAIF SALKNLQDKI RRLELERIQA EESVKTLSRE TIEYKKVLDE QIQERENSKN EESKHNQELT SQLLAAENKC NLLEKQLEYM RNMIKHAEME RTSVLEKQVS LERERQHDQT HVQSQLEKLD LLEQEYNKLT TMQALAEKKM QELEAKLHEE EQERKRMQAK AAELQTGLET NRLIFEDKAT PCVPNARRIK KKKSKPPEKK SSRNYFGAQP HYRLCLGDMP FVAGKSTSPS HAVVANVQLV LHLMKQHSKA LCNDRVINSI PLAKQVSSRG GKSKKLSVTP PSSNGINEEL SEVLQTLQDE FGQMSFDHQQ LAKLIQESPT VELKDKLECE LEALVGRMEA KANQITKVRK YQAQLEKQKL EKQKKELKAT KKTLDEERNS SSRSGITGTT NKKDFMKLRP GEKRRKNLQL LKDMQSIQNS LQSSSLCWDY

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards