About Angiopoietin-related protein 5
Angiopoietin-related protein 5 (ANGPTL5) is a protein
from Homo sapiens identified by UniProt accession
Q86XS5, 388 residues long.
MolForge cross-references it against 0 known binders and
42 disease associations.
Target properties
| Protein name | Angiopoietin-related protein 5 |
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| UniProt accession | Q86XS5 |
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| Gene | ANGPTL5 |
|---|
| Organism | Homo sapiens |
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| Length | 388 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
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Disease associations (42)
Diseases linked to this target (Open Targets).
- monocyte count · score 0.18
- lymphocyte count · score 0.18
- platelet count · score 0.10
- type 2 diabetes mellitus · score 0.08
- neutrophil count · score 0.06
- Obesity · score 0.05
- myeloid sarcoma · score 0.04
- platelet crit · score 0.04
- colorectal adenoma · score 0.04
- colorectal cancer · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q86XS5-F1 | alphafold | PREDICTED | 81.09 | — |
Amino-acid sequence (388 residues)
MMSPSQASLL FLNVCIFICG EAVQGNCVHH STDSSVVNIV EDGSNAKDES KSNDTVCKED CEESCDVKTK ITREEKHFMC RNLQNSIVSY TRSTKKLLRN MMDEQQASLD YLSNQVNELM NRVLLLTTEV FRKQLDPFPH RPVQSHGLDC TDIKDTIGSV TKTPSGLYII HPEGSSYPFE VMCDMDYRGG GRTVIQKRID GIIDFQRLWC DYLDGFGDLL GEFWLGLKKI FYIVNQKNTS FMLYVALESE DDTLAYASYD NFWLEDETRF FKMHLGRYSG NAGDAFRGLK KEDNQNAMPF STSDVDNDGC RPACLVNGQS VKSCSHLHNK TGWWFNECGL ANLNGIHHFS GKLLATGIQW GTWTKNNSPV KIKSVSMKIR RMYNPYFK
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