E3 ubiquitin-protein ligase RNF130 (RNF130)

About E3 ubiquitin-protein ligase RNF130

E3 ubiquitin-protein ligase RNF130 (RNF130) is a protein from Homo sapiens identified by UniProt accession Q86XS8, 419 residues long. MolForge cross-references it against 0 known binders and 52 disease associations.

Target properties

Protein name	E3 ubiquitin-protein ligase RNF130
UniProt accession	Q86XS8
Gene	RNF130
Organism	Homo sapiens
Length	419 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (52)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.37
systolic blood pressure · score 0.36
viral load · score 0.31
insomnia measurement · score 0.15
cortical thickness · score 0.15
leukocyte count · score 0.14
brain measurement · score 0.11
adolescent idiopathic scoliosis · score 0.11
neutrophil percentage of leukocytes · score 0.07
aspartate aminotransferase measurement · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q86XS8-F1	alphafold	PREDICTED	73.99	—

Amino-acid sequence (419 residues)

MSCAGRAGPA RLAALALLTC SLWPARADNA SQEYYTALIN VTVQEPGRGA PLTFRIDRGR YGLDSPKAEV RGQVLAPLPL HGVADHLGCD PQTRFFVPPN IKQWIALLQR GNCTFKEKIS RAAFHNAVAV VIYNNKSKEE PVTMTHPGTG DIIAVMITEL RGKDILSYLE KNISVQMTIA VGTRMPPKNF SRGSLVFVSI SFIVLMIISS AWLIFYFIQK IRYTNARDRN QRRLGDAAKK AISKLTTRTV KKGDKETDPD FDHCAVCIES YKQNDVVRIL PCKHVFHKSC VDPWLSEHCT CPMCKLNILK ALGIVPNLPC TDNVAFDMER LTRTQAVNRR SALGDLAGDN SLGLEPLRTS GISPLPQDGE LTPRTGEINI AVTKEWFIIA SFGLLSALTL CYMIIRATAS LNANEVEWF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards