Vacuolar protein sorting-associated protein 37D…

About Vacuolar protein sorting-associated protein 37D

Vacuolar protein sorting-associated protein 37D (VPS37D) is a protein from Homo sapiens identified by UniProt accession Q86XT2, 251 residues long. MolForge cross-references it against 0 known binders and 25 disease associations.

Target properties

Protein name	Vacuolar protein sorting-associated protein 37D
UniProt accession	Q86XT2
Gene	VPS37D
Organism	Homo sapiens
Length	251 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (25)

Diseases linked to this target (Open Targets).

HIV infection · score 0.53
viral disease · score 0.46
alcohol consumption measurement · score 0.20
mathematical ability · score 0.20
alcohol use disorder measurement · score 0.16
triglyceride measurement · score 0.16
genetic disorder · score 0.12
appendicular lean mass · score 0.09
IGF-1 measurement · score 0.08
testosterone measurement · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q86XT2-F1	alphafold	PREDICTED	79.94	—

Amino-acid sequence (251 residues)

MYRARAARAG PEPGSPGRFG ILSTGQLRDL LQDEPKLDRI VRLSRKFQGL QLEREACLAS NYALAKENLA LRPRLEMGRA ALAIKYQELR EVAENCADKL QRLEESMHRW SPHCALGWLQ AELEEAEQEA EEQMEQLLLG EQSLEAFLPA FQRGRALAHL RRTQAEKLQE LLRRRERSAQ PAPTSAADPP KSFPAAAVLP TGAARGPPAV PRSLPPLDSR PVPPLKGSPG CPLGPAPLLS PRPSQPEPPH R

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Vacuolar protein sorting-associated protein 37D (VPS37D)