Insulin-like growth factor-binding protein 3…

About Insulin-like growth factor-binding protein 3 receptor

Insulin-like growth factor-binding protein 3 receptor (TMEM219) is a protein from Homo sapiens identified by UniProt accession Q86XT9, 240 residues long. MolForge cross-references it against 0 known binders and 70 disease associations.

Target properties

Protein name	Insulin-like growth factor-binding protein 3 receptor
UniProt accession	Q86XT9
Gene	TMEM219
Organism	Homo sapiens
Length	240 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (70)

Diseases linked to this target (Open Targets).

glioblastoma multiforme · score 0.25
neurodegenerative disease · score 0.24
head and neck squamous cell carcinoma · score 0.23
gastric adenocarcinoma · score 0.23
cutaneous melanoma · score 0.18
lean body mass · score 0.13
fat body mass · score 0.13
body mass index · score 0.13
hip circumference · score 0.09
body fat percentage · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q86XT9-F1	alphafold	PREDICTED	67.88	—

Amino-acid sequence (240 residues)

MGNCQAGHNL HLCLAHHPPL VCATLILLLL GLSGLGLGSF LLTHRTGLRS PDIPQDWVSF LRSFGQLTLC PRNGTVTGKW RGSHVVGLLT TLNFGDGPDR NKTRTFQATV LGSQMGLKGS SAGQLVLITA RVTTERTAGT CLYFSAVPGI LPSSQPPISC SEEGAGNATL SPRMGEECVS VWSHEGLVLT KLLTSEELAL CGSRLLVLGS FLLLFCGLLC CVTAMCFHPR RESHWSRTRL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Insulin-like growth factor-binding protein 3 receptor (TMEM219)