About Zinc finger protein 677
Zinc finger protein 677 (ZNF677) is a protein
from Homo sapiens identified by UniProt accession
Q86XU0, 584 residues long.
MolForge cross-references it against 0 known binders and
33 disease associations.
Target properties
| Protein name | Zinc finger protein 677 |
|---|
| UniProt accession | Q86XU0 |
|---|
| Gene | ZNF677 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 584 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (33)
Diseases linked to this target (Open Targets).
- acute myeloid leukemia · score 0.18
- pancreatic adenocarcinoma · score 0.14
- neoplasm · score 0.09
- papillary thyroid carcinoma · score 0.08
- non-small cell lung carcinoma · score 0.08
- renal cell carcinoma · score 0.08
- nonpapillary renal cell carcinoma · score 0.08
- lymph node metastatic carcinoma · score 0.03
- lung adenocarcinoma · score 0.03
- cancer · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q86XU0-F1 | alphafold | PREDICTED | 60.33 | — |
Amino-acid sequence (584 residues)
MALSQGLFTF KDVAIEFSQE EWECLDPAQR ALYRDVMLEN YRNLLSLDED NIPPEDDISV GFTSKGLSPK ENNKEELYHL VILERKESHG INNFDLKEVW ENMPKFDSLW DYDVKNYKGM PLTCNKNLTH RKDQQHNKSS IHFSLKQSVS IRDSAHQYFI HDKPFIRNLL KLKNNIRYAG NKYVKCFENK IGLSLQAQLA ELQRFQTGEK MYECNPVEKS INSSSVSPLP PCVKNICNKY RKILKYPLLH TQYGRTHIRE KSYKCNDCGK AFSKSSNLTN HQRIHSGQRP YKCNECGKAF NQCSNLTRHQ RVHTGEKPYQ CNICGKVCSQ NSNLASHQRM HTGEKPYKCN ECGKAFIQRS HLWGHERIHT GEKPYKCNEC DKAFAERSSL TQHKRIHTGE KPYICNECGK AFKQCSHLTR HQNIHPGEKP HKCNVCGRAF IQSSSLVEHQ RIHTGEKPYK CNKCDKAFIK RSHLWGHQRT HTGEKPYKCT ECGKAFTERS NLTQHKKIHT GEKPYKCTEC GKAFTQFANL TRHQKIHIEK KHCKHNIHGN ALFQSSNLGD HQKSYNREKH IKYNETKIKY SSCT
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