About Spermatogenesis-associated serine-rich protein 2
Spermatogenesis-associated serine-rich protein 2 (SPATS2) is a protein
from Homo sapiens identified by UniProt accession
Q86XZ4, 545 residues long.
MolForge cross-references it against 0 known binders and
40 disease associations.
Target properties
| Protein name | Spermatogenesis-associated serine-rich protein 2 |
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| UniProt accession | Q86XZ4 |
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| Gene | SPATS2 |
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| Organism | Homo sapiens |
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| Length | 545 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (40)
Diseases linked to this target (Open Targets).
- diet measurement · score 0.21
- alcohol consumption measurement · score 0.13
- high density lipoprotein cholesterol measurement · score 0.13
- smoking initiation · score 0.13
- neuroticism measurement · score 0.11
- hepatocellular carcinoma · score 0.11
- alcohol drinking · score 0.08
- esophageal squamous cell carcinoma · score 0.07
- neoplasm · score 0.07
- self reported educational attainment · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q86XZ4-F1 | alphafold | PREDICTED | 63.21 | — |
Amino-acid sequence (545 residues)
MSRKQNQKDS SGFIFDLQSN TVLAQGGAFE NMKEKINAVR AIVPNKSNNE IILVLQHFDN CVDKTVQAFM EGSASEVLKE WTVTGKKKNK KKKNKPKPAA EPSNGIPDSS KSVSIQEEQS APSSEKGGMN GYHVNGAIND TESVDSLSEG LETLSIDARE LEDPESAMLD TLDRTGSMLQ NGVSDFETKS LTMHSIHNSQ QPRNAAKSLS RPTTETQFSN MGMEDVPLAT SKKLSSNIEK SVKDLQRCTV SLARYRVVVK EEMDASIKKM KQAFAELESC LMDREVALLA EMDKVKAEAM EILLSRQKKA ELLKKMTHVA VQMSEQQLVE LRADIKHFVS ERKYDEDLGR VARFTCDVET LKKSIDSFGQ VSHPKNSYST RSRCSSVTSV SLSSPSDASA ASSSTCASPP SLTSANKKNF APGETPAAIA NSSGQPYQPL REVLPGNRRG GQGYRPQGQK SNDPMNQGRH DSMGRYRNSS WYSSGSRYQS APSQAPGNTI ERGQTHSAGT NGTGVSMEPS PPTPSFKKGL PQRKPRTSQT EAVNS
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