About E3 ubiquitin-protein ligase DTX1
E3 ubiquitin-protein ligase DTX1 (DTX1) is a protein
from Homo sapiens identified by UniProt accession
Q86Y01, 620 residues long.
MolForge cross-references it against 0 known binders and
180 disease associations.
Target properties
| Protein name | E3 ubiquitin-protein ligase DTX1 |
|---|
| UniProt accession | Q86Y01 |
|---|
| Gene | DTX1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 620 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (180)
Diseases linked to this target (Open Targets).
- BMI-adjusted waist-hip ratio · score 0.37
- lymphoid neoplasm · score 0.32
- waist-hip ratio · score 0.29
- head and neck squamous cell carcinoma · score 0.23
- ovarian cancer · score 0.18
- endometrial cancer · score 0.18
- breast adenocarcinoma · score 0.18
- diffuse large B-cell lymphoma · score 0.14
- chronic lymphocytic leukemia · score 0.14
- glioblastoma multiforme · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q86Y01-F1 | alphafold | PREDICTED | 74.42 | — |
Amino-acid sequence (620 residues)
MSRPGHGGLM PVNGLGFPPQ NVARVVVWEW LNEHSRWRPY TATVCHHIEN VLKEDARGSV VLGQVDAQLV PYIIDLQSMH QFRQDTGTMR PVRRNFYDPS SAPGKGIVWE WENDGGAWTA YDMDICITIQ NAYEKQHPWL DLSSLGFCYL IYFNSMSQMN RQTRRRRRLR RRLDLAYPLT VGSIPKSQSW PVGASSGQPC SCQQCLLVNS TRAASNAILA SQRRKAPPAP PLPPPPPPGG PPGALAVRPS ATFTGAALWA APAAGPAEPA PPPGAPPRSP GAPGGARTPG QNNLNRPGPQ RTTSVSARAS IPPGVPALPV KNLNGTGPVH PALAGMTGIL LCAAGLPVCL TRAPKPILHP PPVSKSDVKP VPGVPGVCRK TKKKHLKKSK NPEDVVRRYM QKVKNPPDED CTICMERLVT ASGYEGVLRH KGVRPELVGR LGRCGHMYHL LCLVAMYSNG NKDGSLQCPT CKAIYGEKTG TQPPGKMEFH LIPHSLPGFP DTQTIRIVYD IPTGIQGPEH PNPGKKFTAR GFPRHCYLPN NEKGRKVLRL LITAWERRLI FTIGTSNTTG ESDTVVWNEI HHKTEFGSNL TGHGYPDASY LDNVLAELTA QGVSEAAAKA
Explore E3 ubiquitin-protein ligase DTX1 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets