About Serine/threonine-protein kinase VRK2
Serine/threonine-protein kinase VRK2 (VRK2) is a protein
from Homo sapiens identified by UniProt accession
Q86Y07, 508 residues long.
MolForge cross-references it against 0 known binders and
137 disease associations.
Target properties
| Protein name | Serine/threonine-protein kinase VRK2 |
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| UniProt accession | Q86Y07 |
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| Gene | VRK2 |
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| Organism | Homo sapiens |
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| Length | 508 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (3)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (137)
Diseases linked to this target (Open Targets).
- schizophrenia · score 0.48
- bipolar disorder · score 0.46
- unipolar depression · score 0.46
- self reported educational attainment · score 0.46
- neuroticism measurement · score 0.45
- mathematical ability · score 0.45
- diet measurement · score 0.43
- attention deficit hyperactivity disorder · score 0.43
- cortical surface area measurement · score 0.41
- depressive symptom measurement · score 0.41
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q86Y07-F1 | alphafold | PREDICTED | 76.53 | — |
Amino-acid sequence (508 residues)
MPPKRNEKYK LPIPFPEGKV LDDMEGNQWV LGKKIGSGGF GLIYLAFPTN KPEKDARHVV KVEYQENGPL FSELKFYQRV AKKDCIKKWI ERKQLDYLGI PLFYGSGLTE FKGRSYRFMV MERLGIDLQK ISGQNGTFKK STVLQLGIRM LDVLEYIHEN EYVHGDIKAA NLLLGYKNPD QVYLADYGLS YRYCPNGNHK QYQENPRKGH NGTIEFTSLD AHKGVALSRR SDVEILGYCM LRWLCGKLPW EQNLKDPVAV QTAKTNLLDE LPQSVLKWAP SGSSCCEIAQ FLVCAHSLAY DEKPNYQALK KILNPHGIPL GPLDFSTKGQ SINVHTPNSQ KVDSQKAATK QVNKAHNRLI EKKVHSERSA ESCATWKVQK EEKLIGLMNN EAAQESTRRR QKYQESQEPL NEVNSFPQKI SYTQFPNSFY EPHQDFTSPD IFKKSRSPSW YKYTSTVSTG ITDLESSTGL WPTISQFTLS EETNADVYYY RIIIPVLLML VFLALFFL
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