Zinc finger protein 354C (ZNF354C)

About Zinc finger protein 354C

Zinc finger protein 354C (ZNF354C) is a protein from Homo sapiens identified by UniProt accession Q86Y25, 554 residues long. MolForge cross-references it against 0 known binders and 21 disease associations.

Target properties

Protein name	Zinc finger protein 354C
UniProt accession	Q86Y25
Gene	ZNF354C
Organism	Homo sapiens
Length	554 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (21)

Diseases linked to this target (Open Targets).

BMI-adjusted waist circumference · score 0.40
FEV/FVC ratio · score 0.37
body fat distribution · score 0.35
cortical thickness · score 0.34
brain measurement · score 0.32
body height · score 0.31
waist-hip ratio · score 0.27
cortical surface area measurement · score 0.25
refractive error measurement · score 0.08
alkaline phosphatase measurement · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q86Y25-F1	alphafold	PREDICTED	66.08	—

Amino-acid sequence (554 residues)

MAVDLLSAQE PVTFRDVAVF FSQDEWLHLD SAQRALYREV MLENYSSLVS LGIPFSMPKL IHQLQQGEDP CMVEREVPSD TRLGFKTWLE TEALPHRQDI FIEETSQGMV KKESIKDGHW DINFEEAVEF ESEIEEEQEK KPLRQMIDSH EKTISEDGNH TSLELGKSLF TNTALVTQQS VPIERIPNMY YTFGKDFKQN FDLMKCFQIY PGGKPHICNE CGKSFKQNLH LIEHQRIHTG EKPYKCNECE KTFSHRSSLL SHQRIHTGEK PYKCNECEKA FSNSSTLIKH LRVHTGEKPY RCRECGKAFS QCSTLTVHQR IHTGEKLYKC GECEKAFNCR AKLHRHQRIH TGEKPYKCSE CGKGYSQFTS LAEHQRFHTG EQLYTCLECG RTFTRIVTLI EHQRIHTGQK PYQCNECEKA FNQYSSFNEH RKIHTGEKLY TCEECGKAFG CKSNLYRHQR IHTGEKPYQC NQCGKAFSQY SFLTEHERIH TGEKLYKCME CGKAYSYRSN LCRHKKVHTK EKLYKWKEYG KPFICSSSLT QYQRFFKGDK AYEV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards