About Cell division cycle protein 20 homolog B
Cell division cycle protein 20 homolog B (CDC20B) is a protein
from Homo sapiens identified by UniProt accession
Q86Y33, 519 residues long.
MolForge cross-references it against 0 known binders and
59 disease associations.
Target properties
| Protein name | Cell division cycle protein 20 homolog B |
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| UniProt accession | Q86Y33 |
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| Gene | CDC20B |
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| Organism | Homo sapiens |
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| Length | 519 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (59)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.34
- primary familial polycythemia due to EPO receptor mutation · score 0.08
- hemolytic anemia due to diphosphoglycerate mutase deficiency · score 0.06
- erythrocytosis, familial, 3 · score 0.06
- erythrocytosis, familial, 6 · score 0.06
- eosinophil count · score 0.05
- Pyruvate kinase hyperactivity · score 0.05
- erythrocytosis, familial, 4 · score 0.05
- hemoglobin E-beta-thalassemia syndrome · score 0.05
- dehydrated hereditary stomatocytosis · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q86Y33-F1 | alphafold | PREDICTED | 69.75 | — |
Amino-acid sequence (519 residues)
MEWKLERTAP RRVRTEEEML WESIMRVLSK DLKQKRSQDS ANVLDSVNAT YSDFKSNFAK RLSAEVPVAS SPITTRWQQS QTRALSSDSF GEEQSTTYLP EASGSVLKTP PEKETLTLGS RKEQLKTPSK GISETSNSAL HFCKAPHAMD RDWKESVASK GQKCLKQLFV TQNVVQQANG KMQLCEQSEC VWKGCKDGVR DESFHLKSSG DINDSILQPE VKIHITGLRN DYYLNILDWS FQNLVAIALG SAVYIWNGEN HNGIENIDLS LTCNYISSVS WIKEGTCLAV GTSEGEVQLW DVVTKKRLRN MLGHLSVVGA LSWNHFILSS GSRLGRVYHH DVRVAQHHVG TLRHKQAVCA LKWSPDGRLL SSGCSDGLLT IWPHDPGASA QGQPLKVITQ STAVKAMDWC PWQSGVLAIG GGMKDGRLHI LDINAGKSIQ TPSTNSQICS LIWLPKTKEI ATGQGTPKND VTVWTCPTVS RSGGFFGHRG RVLHLSLSPD QTRVFSAAAD GTASVWNCY
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