About Adhesion G protein-coupled receptor G3
Adhesion G protein-coupled receptor G3 (ADGRG3) is a protein
from Homo sapiens identified by UniProt accession
Q86Y34, 549 residues long.
MolForge cross-references it against 0 known binders and
221 disease associations.
Target properties
| Protein name | Adhesion G protein-coupled receptor G3 |
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| UniProt accession | Q86Y34 |
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| Gene | ADGRG3 |
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| Organism | Homo sapiens |
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| Length | 549 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (221)
Diseases linked to this target (Open Targets).
- prostate carcinoma · score 0.11
- isolated agammaglobulinemia · score 0.07
- common variable immunodeficiency · score 0.07
- high density lipoprotein cholesterol measurement · score 0.07
- ICF syndrome · score 0.07
- erythrocyte count · score 0.06
- immunodeficiency 72 with autoinflammation · score 0.06
- severe combined immunodeficiency due to CARD11 deficiency · score 0.06
- BENTA disease · score 0.06
- gamma chain deficiency · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q86Y34-F1 | alphafold | PREDICTED | 80.12 | — |
Amino-acid sequence (549 residues)
MATPRGLGAL LLLLLLPTSG QEKPTEGPRN TCLGSNNMYD IFNLNDKALC FTKCRQSGSD SCNVENLQRY WLNYEAHLMK EGLTQKVNTP FLKALVQNLS TNTAEDFYFS LEPSQVPRQV MKDEDKPPDR VRLPKSLFRS LPGNRSVVRL AVTILDIGPG TLFKGPRLGL GDGSGVLNNR LVGLSVGQMH VTKLAEPLEI VFSHQRPPPN MTLTCVFWDV TKGTTGDWSS EGCSTEVRPE GTVCCCDHLT FFALLLRPTL DQSTVHILTR ISQAGCGVSM IFLAFTIILY AFLRLSRERF KSEDAPKIHV ALGGSLFLLN LAFLVNVGSG SKGSDAACWA RGAVFHYFLL CAFTWMGLEA FHLYLLAVRV FNTYFGHYFL KLSLVGWGLP ALMVIGTGSA NSYGLYTIRD RENRTSLELC WFREGTTMYA LYITVHGYFL ITFLFGMVVL ALVVWKIFTL SRATAVKERG KNRKKVLTLL GLSSLVGVTW GLAIFTPLGL STVYIFALFN SLQGVFICCW FTILYLPSQS TTVSSSTARL DQAHSASQE
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