CDK2-associated and cullin domain-containing protein 1 (CACUL1)

About CDK2-associated and cullin domain-containing protein 1

CDK2-associated and cullin domain-containing protein 1 (CACUL1) is a protein from Homo sapiens identified by UniProt accession Q86Y37, 369 residues long. MolForge cross-references it against 0 known binders and 105 disease associations.

Target properties

Protein name	CDK2-associated and cullin domain-containing protein 1
UniProt accession	Q86Y37
Gene	CACUL1
Organism	Homo sapiens
Length	369 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q86Y37-F1	alphafold	PREDICTED	72.61	—

Amino-acid sequence (369 residues)

MEESMEEEEG GSYEAMMDDQ NHNNWEAAVD GFRQPLPPPP PPSSIPAPAR EPPGGQLLAV PAVSVDRKGP KEGLPMGPQP PPEANGVIMM LKSCDAAAAV AKAAPAPTAS STININTSTS KFLMNVITIE DYKSTYWPKL DGAIDQLLTQ SPGDYIPISY EQIYSCVYKC VCQQHSEQMY SDLIKKITNH LERVSKELQA SPPDLYIERF NIALGQYMGA LQSIVPLFIY MNKFYIETKL NRDLKDDLIK LFTEHVAEKH IYSLMPLLLE AQSTPFQVTP STMANIVKGL YTLRPEWVQM APTLFSKFIP NILPPAVESE LSEYAAQDQK FQRELIQNGF TRGDQSRKRA GDELAYNSSS ACASSRGYR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards