Keratin, type II cytoskeletal 73 (KRT73)

About Keratin, type II cytoskeletal 73

Keratin, type II cytoskeletal 73 (KRT73) is a protein from Homo sapiens identified by UniProt accession Q86Y46, 540 residues long. MolForge cross-references it against 0 known binders and 22 disease associations.

Target properties

Protein name	Keratin, type II cytoskeletal 73
UniProt accession	Q86Y46
Gene	KRT73
Organism	Homo sapiens
Length	540 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (22)

Diseases linked to this target (Open Targets).

clear cell renal carcinoma · score 0.18
head and neck squamous cell carcinoma · score 0.18
prostate adenocarcinoma · score 0.18
ovarian cancer · score 0.18
breast adenocarcinoma · score 0.18
esophageal cancer · score 0.14
low grade glioma · score 0.11
appendicitis · score 0.07
disorder of appendix · score 0.06
hair colour measurement · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q86Y46-F1	alphafold	PREDICTED	68.80	—

Amino-acid sequence (540 residues)

MSRQFTYKSG AAAKGGFSGC SAVLSGGSSS SYRAGGKGLS GGFSSRSLYS LGGARSISFN VASGSGWAGG YGFGRGRASG FAGSMFGSVA LGSVCPSLCP PGGIHQVTIN KSLLAPLNVE LDPEIQKVRA QEREQIKVLN NKFASFIDKV RFLEQQNQVL ETKWELLQQL DLNNCKNNLE PILEGYISNL RKQLETLSGD RVRLDSELRS VREVVEDYKK RYEEEINKRT TAENEFVVLK KDVDAAYTSK VELQAKVDAL DGEIKFFKCL YEGETAQIQS HISDTSIILS MDNNRNLDLD SIIAEVRAQY EEIARKSKAE AEALYQTKFQ ELQLAAGRHG DDLKHTKNEI SELTRLIQRL RSEIESVKKQ CANLETAIAD AEQRGDCALK DARAKLDELE GALQQAKEEL ARMLREYQEL LSVKLSLDIE IATYRKLLEG EECRMSGEYT NSVSISVINS SMAGMAGTGA GFGFSNAGTY GYWPSSVSGG YSMLPGGCVT GSGNCSPRGE ARTRLGSASE FRDSQGKTLA LSSPTKKTMR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards