Ly6/PLAUR domain-containing protein 6 (LYPD6)

About Ly6/PLAUR domain-containing protein 6

Ly6/PLAUR domain-containing protein 6 (LYPD6) is a protein from Homo sapiens identified by UniProt accession Q86Y78, 171 residues long. MolForge cross-references it against 0 known binders and 37 disease associations.

Target properties

Protein name	Ly6/PLAUR domain-containing protein 6
UniProt accession	Q86Y78
Gene	LYPD6
Organism	Homo sapiens
Length	171 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (37)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.31
Vertigo · score 0.25
body weight · score 0.18
neuroimaging measurement · score 0.10
cortical surface area measurement · score 0.10
brain measurement · score 0.09
brain volume measurement · score 0.08
PHF-tau measurement · score 0.06
reticulocyte measurement · score 0.06
reticulocyte count · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q86Y78-F1	alphafold	PREDICTED	86.10	—

Amino-acid sequence (171 residues)

MEPGPALAWL LLLSLLADCL KAAQSRDFTV KDIIYLHPST TPYPGGFKCF TCEKAADNYE CNRWAPDIYC PRETRYCYTQ HTMEVTGNSI SVTKRCVPLE ECLSTGCRDS EHEGHKVCTS CCEGNICNLP LPRNETDATF ATTSPINQTN GHPRCMSVIV SCLWLWLGLM L

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards