About Syntaxin-12
Syntaxin-12 (STX12) is a protein
from Homo sapiens identified by UniProt accession
Q86Y82, 276 residues long.
MolForge cross-references it against 0 known binders and
18 disease associations.
Target properties
| Protein name | Syntaxin-12 |
|---|
| UniProt accession | Q86Y82 |
|---|
| Gene | STX12 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 276 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (18)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.48
- platelet count · score 0.18
- myeloid white cell count · score 0.05
- type 2 diabetes mellitus · score 0.04
- hepatocellular carcinoma · score 0.04
- basophil count · score 0.03
- neoplasm · score 0.03
- lymphocyte count · score 0.02
- neuroblastoma · score 0.01
- ovarian carcinoma · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q86Y82-F1 | alphafold | PREDICTED | 80.27 | — |
Amino-acid sequence (276 residues)
MSYGPLDMYR NPGPSGPQLR DFSSIIQTCS GNIQRISQAT AQIKNLMSQL GTKQDSSKLQ ENLQQLQHST NQLAKETNEL LKELGSLPLP LSTSEQRQQR LQKERLMNDF SAALNNFQAV QRRVSEKEKE SIARARAGSR LSAEERQREE QLVSFDSHEE WNQMQSQEDE VAITEQDLEL IKERETAIRQ LEADILDVNQ IFKDLAMMIH DQGDLIDSIE ANVESSEVHV ERATEQLQRA AYYQKKSRKK MCILVLVLSV IILILGLIIW LVYKTK
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