About 5'-3' DNA helicase ZGRF1
5'-3' DNA helicase ZGRF1 (ZGRF1) is a protein
from Homo sapiens identified by UniProt accession
Q86YA3, 2104 residues long.
MolForge cross-references it against 0 known binders and
33 disease associations.
Target properties
| Protein name | 5'-3' DNA helicase ZGRF1 |
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| UniProt accession | Q86YA3 |
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| Gene | ZGRF1 |
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| Organism | Homo sapiens |
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| Length | 2104 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (33)
Diseases linked to this target (Open Targets).
- childhood apraxia of speech · score 0.32
- autism spectrum disorder · score 0.32
- brain measurement · score 0.22
- neuroimaging measurement · score 0.20
- protein measurement · score 0.20
- cortical surface area measurement · score 0.17
- appendicular lean mass · score 0.16
- alcohol consumption measurement · score 0.16
- forced expiratory volume · score 0.16
- cortical thickness · score 0.14
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q86YA3-F1 | alphafold | PREDICTED | 49.96 | — |
Amino-acid sequence (2104 residues)
MESQEFIVLY THQKMKKSKV WQDGILKITH LGNKAILYDD KGACLESLFL KCLEVKPGDD LESDRYLITV EEVKVAGAIG IVKQNVNKEA PELNSRTFIS SGRSLGCQPS GLKRKFTGFQ GPRQVPKKMV IMESGESAAS HEAKKTGPTI FSPFCSMPPL FPTVGKKDVN NILADPENIV TYKNRERNAM DFSSVFSPSF QINPEVLCEE NYFCSPVNSG NKLSDSLLTN EPVKRDSLAS HYSGVSQNIR SKAQILALLK SESSSSCEEL NSEMTEHFPQ KQPQGSLKIA TKPKYLIQQE ECAEMKSTEN LYYQHQSENT MRNKSRWAMY LSSQSSPIHS STVDGNDTER KPKAQEDDVN SNLKDLSLQK IIQFVETYAE ERKKYNVDQS VGNNDPSWNQ EVKLEIPSFN ESSSLQVTCS SAENDGILSE SDIQEDNKIP FNQNDKGCIK GSVLIKENAQ EVNTCGTLEK EYEQSESSLP ELKHLQIESS NNSRISDDIT DMISESKMDN ESLNSIHESL SNVTQPFLEV TFNLNNFETS DTEEESQESN KISQDSESWV KDILVNDGNS CFQKRSENTN CEEIEGEHLP FLTSVSDKPT VTFPVKETLP SQFCDKTYVG FDMGICKTEN TGKEIEEYSD TLSNFESFKW TDAVYGDNKE DANKPIQEVR INYDFALPPN KSKGINMNLH IPHIQNQIAE NSNLFSEDAQ PQPFILGSDL DKNDEHVLPS TSSSDNSVQL LNTNQNHYEC IALDKSNTHI SNSLFYPLGK KHLISKDTEA HISEPEDLGK IRSPPPDHVE VETAREGKQY WNPRNSSELS GLVNTISILK SLCEHSTALD SLEILKKKNT VFQQGTQQTY EPDSPPEVRK PFITVVSPKS PHLHKDSQQI LKEDEVELSE PLQSVQFSSS GSKEETAFQA VIPKQIERKT CDPKPVEFQG HQVKGSATSG VMVRGHSSQL GCSQFPDSTE YENFMTETPE LPSTCMQIDF LQVTSPEENI STLSPVSTFS LNSRDEDFMV EFSETSLKAR TLPDDLHFLN LEGMKKSRSL ENENLQRLSL LSRTQVPLIT LPRTDGPPDL DSHSYMINSN TYESSGSPML NLCEKSAVLS FSIEPEDQNE TFFSEESREV NPGDVSLNNI STQSKWLKYQ NTSQCNVATP NRVDKRITDG FFAEAVSGMH FRDTSERQSD AVNESSLDSV HLQMIKGMLY QQRQDFSSQD SVSRKKVLSL NLKQTSKTEE IKNVLGGSTC YNYSVKDLQE ISGSELCFPS GQKIKSAYLP QRQIHIPAVF QSPAHYKQTF TSCLIEHLNI LLFGLAQNLQ KALSKVDISF YTSLKGEKLK NAENNVPSCH HSQPAKLVMV KKEGPNKGRL FYTCDGPKAD RCKFFKWLED VTPGYSTQEG ARPGMVLSDI KSIGLYLRSQ KIPLYEECQL LVRKGFDFQR KQYGKLKKFT TVNPEFYNEP KTKLYLKLSR KERSSAYSKN DLWVVSKTLD FELDTFIACS AFFGPSSINE IEILPLKGYF PSNWPTNMVV HALLVCNAST ELTTLKNIQD YFNPATLPLT QYLLTTSSPT IVSNKRVSKR KFIPPAFTNV STKFELLSLG ATLKLASELI QVHKLNKDQA TALIQIAQMM ASHESIEEVK ELQTHTFPIT IIHGVFGAGK SYLLAVVILF FVQLFEKSEA PTIGNARPWK LLISSSTNVA VDRVLLGLLS LGFENFIRVG SVRKIAKPIL PYSLHAGSEN ESEQLKELHA LMKEDLTPTE RVYVRKSIEQ HKLGTNRTLL KQVRVVGVTC AACPFPCMND LKFPVVVLDE CSQITEPASL LPIARFECEK LILVGDPKQL PPTIQGSDAA HENGLEQTLF DRLCLMGHKP ILLRTQYRCH PAISAIANDL FYKGALMNGV TEIERSPLLE WLPTLCFYNV KGLEQIERDN SFHNVAEATF TLKLIQSLIA SGIAGSMIGV ITLYKSQMYK LCHLLSAVDF HHPDIKTVQV STVDAFQGAE KEIIILSCVR TRQVGFIDSE KRMNVALTRG KRHLLIVGNL ACLRKNQLWG RVIQHCEGRE DGLQHANQYE PQLNHLLKDY FEKQVEEKQK KKSEKEKSKD KSHS
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