ERO1-like protein beta (ERO1B)

About ERO1-like protein beta

ERO1-like protein beta (ERO1B) is a protein from Homo sapiens identified by UniProt accession Q86YB8, 467 residues long. MolForge cross-references it against 0 known binders and 74 disease associations.

Target properties

Protein name	ERO1-like protein beta
UniProt accession	Q86YB8
Gene	ERO1B
Organism	Homo sapiens
Length	467 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (74)

Diseases linked to this target (Open Targets).

blood protein measurement · score 0.29
bone benign neoplasm · score 0.26
endometrial cancer · score 0.18
cortical surface area measurement · score 0.13
early-onset non-syndromic cataract · score 0.12
Developmental cataract · score 0.12
brain measurement · score 0.10
MODY · score 0.10
type 2 diabetes mellitus · score 0.09
type 1 diabetes mellitus · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q86YB8-F1	alphafold	PREDICTED	75.62	—

Amino-acid sequence (467 residues)

MSQGVRRAGA GQGVAAAVQL LVTLSFLRSV VEAQVTGVLD DCLCDIDSID NFNTYKIFPK IKKLQERDYF RYYKVNLKRP CPFWAEDGHC SIKDCHVEPC PESKIPVGIK AGHSNKYLKM ANNTKELEDC EQANKLGAIN STLSNQSKEA FIDWARYDDS RDHFCELDDE RSPAAQYVDL LLNPERYTGY KGTSAWRVWN SIYEENCFKP RSVYRPLNPL APSRGEDDGE SFYTWLEGLC LEKRVFYKLI SGLHASINLH LCANYLLEET WGKPSWGPNI KEFKHRFDPV ETKGEGPRRL KNLYFLYLIE LRALSKVAPY FERSIVDLYT GNAEEDADTK TLLLNIFQDT KSFPMHFDEK SMFAGDKKGA KSLKEEFRLH FKNISRIMDC VGCDKCRLWG KLQTQGLGTA LKILFSEKEI QKLPENSPSK GFQLTRQEIV ALLNAFGRLS TSIRDLQNFK VLLQHSR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards