About Transforming growth factor beta activator LRRC33
Transforming growth factor beta activator LRRC33 (NRROS) is a protein
from Homo sapiens identified by UniProt accession
Q86YC3, 692 residues long.
MolForge cross-references it against 0 known binders and
52 disease associations.
Target properties
| Protein name | Transforming growth factor beta activator LRRC33 |
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| UniProt accession | Q86YC3 |
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| Gene | NRROS |
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| Organism | Homo sapiens |
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| Length | 692 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (52)
Diseases linked to this target (Open Targets).
- seizures, early-onset, with neurodegeneration and brain calcifications · score 0.72
- asthma · score 0.40
- eosinophil count · score 0.39
- Eczematoid dermatitis · score 0.37
- allergic rhinitis · score 0.33
- allergic disease · score 0.33
- eosinophil percentage of leukocytes · score 0.32
- gut microbiome measurement · score 0.28
- atopic asthma · score 0.28
- Inhalant adrenergic use measurement · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q86YC3-F1 | alphafold | PREDICTED | 83.31 | — |
Amino-acid sequence (692 residues)
MELLPLWLCL GFHFLTVGWR NRSGTATAAS QGVCKLVGGA ADCRGQSLAS VPSSLPPHAR MLTLDANPLK TLWNHSLQPY PLLESLSLHS CHLERISRGA FQEQGHLRSL VLGDNCLSEN YEETAAALHA LPGLRRLDLS GNALTEDMAA LMLQNLSSLR SVSLAGNTIM RLDDSVFEGL ERLRELDLQR NYIFEIEGGA FDGLAELRHL NLAFNNLPCI VDFGLTRLRV LNVSYNVLEW FLATGGEAAF ELETLDLSHN QLLFFPLLPQ YSKLRTLLLR DNNMGFYRDL YNTSSPREMV AQFLLVDGNV TNITTVSLWE EFSSSDLADL RFLDMSQNQF QYLPDGFLRK MPSLSHLNLH QNCLMTLHIR EHEPPGALTE LDLSHNQLSE LHLAPGLASC LGSLRLFNLS SNQLLGVPPG LFANARNITT LDMSHNQISL CPLPAASDRV GPPSCVDFRN MASLRSLSLE GCGLGALPDC PFQGTSLTYL DLSSNWGVLN GSLAPLQDVA PMLQVLSLRN MGLHSSFMAL DFSGFGNLRD LDLSGNCLTT FPRFGGSLAL ETLDLRRNSL TALPQKAVSE QLSRGLRTIY LSQNPYDCCG VDGWGALQHG QTVADWAMVT CNLSSKIIRV TELPGGVPRD CKWERLDLGL LYLVLILPSC LTLLVACTVI VLTFKKPLLQ VIKSRCHWSS VY
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