Transmembrane protein 25 (TMEM25)

About Transmembrane protein 25

Transmembrane protein 25 (TMEM25) is a protein from Homo sapiens identified by UniProt accession Q86YD3, 366 residues long. MolForge cross-references it against 0 known binders and 22 disease associations.

Target properties

Protein name	Transmembrane protein 25
UniProt accession	Q86YD3
Gene	TMEM25
Organism	Homo sapiens
Length	366 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (22)

Diseases linked to this target (Open Targets).

high density lipoprotein cholesterol measurement · score 0.21
apolipoprotein A 1 measurement · score 0.17
total cholesterol measurement · score 0.09
neoplasm · score 0.08
triple-negative breast cancer · score 0.08
nonpapillary renal cell carcinoma · score 0.07
psoriasis · score 0.04
hepatocellular carcinoma · score 0.03
cancer · score 0.02
Crohn's disease · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q86YD3-F1	alphafold	PREDICTED	62.86	—

Amino-acid sequence (366 residues)

MALPPGPAAL RHTLLLLPAL LSSGWGELEP QIDGQTWAER ALRENERHAF TCRVAGGPGT PRLAWYLDGQ LQEASTSRLL SVGGEAFSGG TSTFTVTAHR AQHELNCSLQ DPRSGRSANA SVILNVQFKP EIAQVGAKYQ EAQGPGLLVV LFALVRANPP ANVTWIDQDG PVTVNTSDFL VLDAQNYPWL TNHTVQLQLR SLAHNLSVVA TNDVGVTSAS LPAPGLLATR VEVPLLGIVV AAGLALGTLV GFSTLVACLV CRKEKKTKGP SRHPSLISSD SNNLKLNNVR LPRENMSLPS NLQLNDLTPD SRAVKPADRQ MAQNNSRPEL LDPEPGGLLT SQGFIRLPVL GYIYRVSSVS SDEIWL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards